Cuproptosis-related genes are involved in immunodeficiency following ischemic stroke
Introduction Accumulating studies have shown that copper has a detrimental effect in cells, and the cuproptosis-related gene signatures have been constructed as clinical tools to predict prognosis in tumors. However, the heterogeneity of cuproptosis has not been fully investigated in ischemic stroke...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2024-01-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Cuproptosis-related-genes-are-involved-in-immunodeficiency-following-ischemic-stroke,182909,0,2.html |
| _version_ | 1797214536732770304 |
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| author | Jinshi Li Cong Yu Shu Liang Dabin Ren Ping Zheng |
| author_facet | Jinshi Li Cong Yu Shu Liang Dabin Ren Ping Zheng |
| author_sort | Jinshi Li |
| collection | DOAJ |
| description | Introduction
Accumulating studies have shown that copper has a detrimental effect in cells, and the cuproptosis-related gene signatures have been constructed as clinical tools to predict prognosis in tumors. However, the heterogeneity of cuproptosis has not been fully investigated in ischemic stroke.
Material and methods
Here, we combined the bulk RNA-seq and single cell-RNA-seq data for stroke to investigate the role of cuproptosis in stroke.
Results
We identified the cuproptosis-related differentially expressed genes (CuDEGs) in ischemic stroke. Then, we tried to find the hub genes with the machine learning method and WGCNA. We highlighted four genes identified by these methods and proposed a potential diagnostic model in ischemic stroke.
Conclusions
Our findings revealed cuproptosis-related hub genes, which could provide useful biomarkers in ischemic stroke. |
| first_indexed | 2024-04-24T11:15:44Z |
| format | Article |
| id | doaj.art-1bef75bed4d849ac97d980e667a22c22 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-04-24T11:15:44Z |
| publishDate | 2024-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-1bef75bed4d849ac97d980e667a22c222024-04-11T08:11:16ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-01-0120132132510.5114/aoms/182909182909Cuproptosis-related genes are involved in immunodeficiency following ischemic strokeJinshi Li0Cong Yu1Shu Liang2Dabin Ren3Ping Zheng4Department of Neurology, Shanghai Pudong New Area People’s Hospital, Shanghai, ChinaDepartment of Neurosurgery, Shanghai Pudong New Area People’s Hospital, Shanghai, ChinaDepartment of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Shanghai Pudong New Area People’s Hospital, Shanghai, ChinaDepartment of Neurosurgery, Shanghai Pudong New Area People’s Hospital, Shanghai, ChinaIntroduction Accumulating studies have shown that copper has a detrimental effect in cells, and the cuproptosis-related gene signatures have been constructed as clinical tools to predict prognosis in tumors. However, the heterogeneity of cuproptosis has not been fully investigated in ischemic stroke. Material and methods Here, we combined the bulk RNA-seq and single cell-RNA-seq data for stroke to investigate the role of cuproptosis in stroke. Results We identified the cuproptosis-related differentially expressed genes (CuDEGs) in ischemic stroke. Then, we tried to find the hub genes with the machine learning method and WGCNA. We highlighted four genes identified by these methods and proposed a potential diagnostic model in ischemic stroke. Conclusions Our findings revealed cuproptosis-related hub genes, which could provide useful biomarkers in ischemic stroke.https://www.archivesofmedicalscience.com/Cuproptosis-related-genes-are-involved-in-immunodeficiency-following-ischemic-stroke,182909,0,2.htmlstrokegeocoppercuproptosissingle cell-rna sequencingnlrp3 |
| spellingShingle | Jinshi Li Cong Yu Shu Liang Dabin Ren Ping Zheng Cuproptosis-related genes are involved in immunodeficiency following ischemic stroke Archives of Medical Science stroke geo copper cuproptosis single cell-rna sequencing nlrp3 |
| title | Cuproptosis-related genes are involved in immunodeficiency following ischemic stroke |
| title_full | Cuproptosis-related genes are involved in immunodeficiency following ischemic stroke |
| title_fullStr | Cuproptosis-related genes are involved in immunodeficiency following ischemic stroke |
| title_full_unstemmed | Cuproptosis-related genes are involved in immunodeficiency following ischemic stroke |
| title_short | Cuproptosis-related genes are involved in immunodeficiency following ischemic stroke |
| title_sort | cuproptosis related genes are involved in immunodeficiency following ischemic stroke |
| topic | stroke geo copper cuproptosis single cell-rna sequencing nlrp3 |
| url | https://www.archivesofmedicalscience.com/Cuproptosis-related-genes-are-involved-in-immunodeficiency-following-ischemic-stroke,182909,0,2.html |
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