Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate
The in vitro stability of 99mTc(Sn)-pyrophosphate solution was examined in dependence on the preparation conditions of the samples, the radioactive concentration of 99mTc in the kit and the time elapsed after labeling. The samples without any protection are highly unstable. The formation of 99mTc-pe...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
1999-05-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | http://www.shd.org.yu/HtDocs/SHD/Vol64/No5-Pdf/V64-no5&6-6.zip |
| _version_ | 1818347529277800448 |
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| author | JURIJ L. VUCINA |
| author_facet | JURIJ L. VUCINA |
| author_sort | JURIJ L. VUCINA |
| collection | DOAJ |
| description | The in vitro stability of 99mTc(Sn)-pyrophosphate solution was examined in dependence on the preparation conditions of the samples, the radioactive concentration of 99mTc in the kit and the time elapsed after labeling. The samples without any protection are highly unstable. The formation of 99mTc-pertechnetate does not depend on the radioactive concentration. Nitrogen purging provides protection in the case of low radioactive concentrations (37 MBq 99mTc/ml) but exhibits no effect at higher concentrations. The best stabilization was achieved by using ascorbic acid. A concentration of 60 µg/ml keeps the content of 99mTc-pertechnetate below 1% during six hours after labeling, even in solutions of high readioactive concentrations (740-814 MBq/ml). Gentisic acid is less effective. Concentrations about ten times higher than required using ascorbic acid are needed to keep the content of 99mTc-pertechnetate below 5% during six hours. |
| first_indexed | 2024-12-13T17:35:36Z |
| format | Article |
| id | doaj.art-1bf0bcc21f7c47219fdc0238f7df8b29 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-13T17:35:36Z |
| publishDate | 1999-05-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-1bf0bcc21f7c47219fdc0238f7df8b292022-12-21T23:36:55ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391999-05-01645-6375380Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphateJURIJ L. VUCINAThe in vitro stability of 99mTc(Sn)-pyrophosphate solution was examined in dependence on the preparation conditions of the samples, the radioactive concentration of 99mTc in the kit and the time elapsed after labeling. The samples without any protection are highly unstable. The formation of 99mTc-pertechnetate does not depend on the radioactive concentration. Nitrogen purging provides protection in the case of low radioactive concentrations (37 MBq 99mTc/ml) but exhibits no effect at higher concentrations. The best stabilization was achieved by using ascorbic acid. A concentration of 60 µg/ml keeps the content of 99mTc-pertechnetate below 1% during six hours after labeling, even in solutions of high readioactive concentrations (740-814 MBq/ml). Gentisic acid is less effective. Concentrations about ten times higher than required using ascorbic acid are needed to keep the content of 99mTc-pertechnetate below 5% during six hours.http://www.shd.org.yu/HtDocs/SHD/Vol64/No5-Pdf/V64-no5&6-6.zippyrophosphatetechnetium-99mascorbic acidgentisic acidchemical stabilization |
| spellingShingle | JURIJ L. VUCINA Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate Journal of the Serbian Chemical Society pyrophosphate technetium-99m ascorbic acid gentisic acid chemical stabilization |
| title | Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate |
| title_full | Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate |
| title_fullStr | Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate |
| title_full_unstemmed | Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate |
| title_short | Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate |
| title_sort | influence of the radioactive concentration of the in vitro stability of tc 99m sn pyrophosphate |
| topic | pyrophosphate technetium-99m ascorbic acid gentisic acid chemical stabilization |
| url | http://www.shd.org.yu/HtDocs/SHD/Vol64/No5-Pdf/V64-no5&6-6.zip |
| work_keys_str_mv | AT jurijlvucina influenceoftheradioactiveconcentrationoftheinvitrostabilityoftc99msnpyrophosphate |