Radiation Recall Dermatitis Following Treatment With Pembrolizumab: A Case Report and Review of the Literature
Radiation recall dermatitis is an inflammatory reaction of the skin that may infrequently occur in areas of the skin that have been previously treated with radiation therapy. This is thought to be due to a triggering agent administered after radiation therapy which leads to an acute inflammatory rea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-04-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/23247096231168114 |
| _version_ | 1797839586228961280 |
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| author | Michael Sandhu Prashanth Ashok Kumar Jared Deck Maroun Bou Zerdan Michael Lacombe Abirami Sivapiragasam |
| author_facet | Michael Sandhu Prashanth Ashok Kumar Jared Deck Maroun Bou Zerdan Michael Lacombe Abirami Sivapiragasam |
| author_sort | Michael Sandhu |
| collection | DOAJ |
| description | Radiation recall dermatitis is an inflammatory reaction of the skin that may infrequently occur in areas of the skin that have been previously treated with radiation therapy. This is thought to be due to a triggering agent administered after radiation therapy which leads to an acute inflammatory reaction, manifesting as a skin rash. We present the case of a 58-year-old male with recurrent invasive squamous cell carcinoma of the tongue, previously treated with chemotherapy and radiation therapy, who presented with progression of his disease. He was treated with pembrolizumab and subsequently developed a new-onset facial rash over the previously treated radiation field. The distribution of the rash was suggestive of radiation recall dermatitis. A biopsy showed dermal necrosis without evidence of dermatitis, vasculitis, or infectious process. This case highlights the incidence of a rare complication of immune checkpoint inhibitor therapy and emphasizes the need for careful monitoring for radiation recall dermatitis. |
| first_indexed | 2024-04-09T16:00:22Z |
| format | Article |
| id | doaj.art-1bf1bcffd59342aca09332c4ded27cb6 |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-04-09T16:00:22Z |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-1bf1bcffd59342aca09332c4ded27cb62023-04-25T11:33:32ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962023-04-011110.1177/23247096231168114Radiation Recall Dermatitis Following Treatment With Pembrolizumab: A Case Report and Review of the LiteratureMichael Sandhu0Prashanth Ashok Kumar1Jared Deck2Maroun Bou Zerdan3Michael Lacombe4Abirami Sivapiragasam5SUNY Upstate Medical University, Syracuse, USASUNY Upstate Medical University, Syracuse, USASUNY Upstate Medical University, Syracuse, USASUNY Upstate Medical University, Syracuse, USASUNY Upstate Medical University, Syracuse, USASUNY Upstate Medical University, Syracuse, USARadiation recall dermatitis is an inflammatory reaction of the skin that may infrequently occur in areas of the skin that have been previously treated with radiation therapy. This is thought to be due to a triggering agent administered after radiation therapy which leads to an acute inflammatory reaction, manifesting as a skin rash. We present the case of a 58-year-old male with recurrent invasive squamous cell carcinoma of the tongue, previously treated with chemotherapy and radiation therapy, who presented with progression of his disease. He was treated with pembrolizumab and subsequently developed a new-onset facial rash over the previously treated radiation field. The distribution of the rash was suggestive of radiation recall dermatitis. A biopsy showed dermal necrosis without evidence of dermatitis, vasculitis, or infectious process. This case highlights the incidence of a rare complication of immune checkpoint inhibitor therapy and emphasizes the need for careful monitoring for radiation recall dermatitis.https://doi.org/10.1177/23247096231168114 |
| spellingShingle | Michael Sandhu Prashanth Ashok Kumar Jared Deck Maroun Bou Zerdan Michael Lacombe Abirami Sivapiragasam Radiation Recall Dermatitis Following Treatment With Pembrolizumab: A Case Report and Review of the Literature Journal of Investigative Medicine High Impact Case Reports |
| title | Radiation Recall Dermatitis Following Treatment With Pembrolizumab: A Case Report and Review of the Literature |
| title_full | Radiation Recall Dermatitis Following Treatment With Pembrolizumab: A Case Report and Review of the Literature |
| title_fullStr | Radiation Recall Dermatitis Following Treatment With Pembrolizumab: A Case Report and Review of the Literature |
| title_full_unstemmed | Radiation Recall Dermatitis Following Treatment With Pembrolizumab: A Case Report and Review of the Literature |
| title_short | Radiation Recall Dermatitis Following Treatment With Pembrolizumab: A Case Report and Review of the Literature |
| title_sort | radiation recall dermatitis following treatment with pembrolizumab a case report and review of the literature |
| url | https://doi.org/10.1177/23247096231168114 |
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