Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity
Human milk contains three antibody classes that confer mucosal immunity to the breastfed infant: secretory IgA (SIgA), secretory IgM (SIgM), and IgG. Influenza and pertussis vaccines administered during pregnancy induce pathogen specific SIgA and IgG responses in human milk that have been shown to p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.910383/full |
| _version_ | 1811297171111149568 |
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| author | Soumya Hunagund Yarden Golan Yarden Golan Ifeyinwa V. Asiodu Mary Prahl Mary Prahl Stephanie L. Gaw Stephanie L. Gaw |
| author_facet | Soumya Hunagund Yarden Golan Yarden Golan Ifeyinwa V. Asiodu Mary Prahl Mary Prahl Stephanie L. Gaw Stephanie L. Gaw |
| author_sort | Soumya Hunagund |
| collection | DOAJ |
| description | Human milk contains three antibody classes that confer mucosal immunity to the breastfed infant: secretory IgA (SIgA), secretory IgM (SIgM), and IgG. Influenza and pertussis vaccines administered during pregnancy induce pathogen specific SIgA and IgG responses in human milk that have been shown to protect the breastfed infant from these respiratory illnesses. In addition, mRNA vaccines against the SARS-CoV-2 virus administered during pregnancy and lactation induce anti-SARS-CoV-2 IgG and IgA responses in human milk. This review summarizes the immunologic benefits of influenza, pertussis, and COVID-19 vaccines conferred by human milk. Additionally, future research direction in human milk immunity and public health needs to improve lactational support are discussed. |
| first_indexed | 2024-04-13T05:59:15Z |
| format | Article |
| id | doaj.art-1bf2991a7f9c4eb2b16779c30e61cb32 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T05:59:15Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1bf2991a7f9c4eb2b16779c30e61cb322022-12-22T02:59:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.910383910383Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health EquitySoumya Hunagund0Yarden Golan1Yarden Golan2Ifeyinwa V. Asiodu3Mary Prahl4Mary Prahl5Stephanie L. Gaw6Stephanie L. Gaw7Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United StatesInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Family Health Care Nursing, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Pediatrics, University of California, San Francisco, San Francisco, CA, United StatesDivision of Pediatric Infectious Diseases and Global Health, University of California, San Francisco, San Francisco, CA, United StatesDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United StatesCenter for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United StatesHuman milk contains three antibody classes that confer mucosal immunity to the breastfed infant: secretory IgA (SIgA), secretory IgM (SIgM), and IgG. Influenza and pertussis vaccines administered during pregnancy induce pathogen specific SIgA and IgG responses in human milk that have been shown to protect the breastfed infant from these respiratory illnesses. In addition, mRNA vaccines against the SARS-CoV-2 virus administered during pregnancy and lactation induce anti-SARS-CoV-2 IgG and IgA responses in human milk. This review summarizes the immunologic benefits of influenza, pertussis, and COVID-19 vaccines conferred by human milk. Additionally, future research direction in human milk immunity and public health needs to improve lactational support are discussed.https://www.frontiersin.org/articles/10.3389/fimmu.2022.910383/fullhuman milkCOVID - 19influenzapertussisvaccinationinfant health |
| spellingShingle | Soumya Hunagund Yarden Golan Yarden Golan Ifeyinwa V. Asiodu Mary Prahl Mary Prahl Stephanie L. Gaw Stephanie L. Gaw Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity Frontiers in Immunology human milk COVID - 19 influenza pertussis vaccination infant health |
| title | Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity |
| title_full | Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity |
| title_fullStr | Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity |
| title_full_unstemmed | Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity |
| title_short | Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity |
| title_sort | effects of vaccination against influenza pertussis and covid 19 on human milk antibodies current evidence and implications for health equity |
| topic | human milk COVID - 19 influenza pertussis vaccination infant health |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.910383/full |
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