Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering
The Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21–60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people’s quality of life and increases the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.897010/full |
| _version_ | 1818549339012726784 |
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| author | Senbo Zhu Senbo Zhu Zeju He Zeju He Lichen Ji Lichen Ji Wei Zhang Yu Tong Junchao Luo Junchao Luo Yin Zhang Yong Li Xiang Meng Qing Bi Qing Bi |
| author_facet | Senbo Zhu Senbo Zhu Zeju He Zeju He Lichen Ji Lichen Ji Wei Zhang Yu Tong Junchao Luo Junchao Luo Yin Zhang Yong Li Xiang Meng Qing Bi Qing Bi |
| author_sort | Senbo Zhu |
| collection | DOAJ |
| description | The Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21–60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people’s quality of life and increases the medical burden. Due to its low cellularity and vascular deficiency, AT has a poor healing ability. Therefore, AT injury healing has attracted a lot of attention from researchers. Current AT injury treatment options cannot effectively restore the mechanical structure and function of AT, which promotes the development of AT regenerative tissue engineering. Various nanofiber-based scaffolds are currently being explored due to their structural similarity to natural tendon and their ability to promote tissue regeneration. This review discusses current methods of AT regeneration, recent advances in the fabrication and enhancement of nanofiber-based scaffolds, and the development and use of multiscale nanofiber-based scaffolds for AT regeneration. |
| first_indexed | 2024-12-12T08:32:04Z |
| format | Article |
| id | doaj.art-1bf3307827b246a981eac525dc635776 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T08:32:04Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-1bf3307827b246a981eac525dc6357762022-12-22T00:31:04ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-06-011010.3389/fbioe.2022.897010897010Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative EngineeringSenbo Zhu0Senbo Zhu1Zeju He2Zeju He3Lichen Ji4Lichen Ji5Wei Zhang6Yu Tong7Junchao Luo8Junchao Luo9Yin Zhang10Yong Li11Xiang Meng12Qing Bi13Qing Bi14Center for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaCenter for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaCenter for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaCenter for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaCenter for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaCenter for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaCenter for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaCenter for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaCenter for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaCenter for Rehabilitation Medicine, Department of Orthopedics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21–60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people’s quality of life and increases the medical burden. Due to its low cellularity and vascular deficiency, AT has a poor healing ability. Therefore, AT injury healing has attracted a lot of attention from researchers. Current AT injury treatment options cannot effectively restore the mechanical structure and function of AT, which promotes the development of AT regenerative tissue engineering. Various nanofiber-based scaffolds are currently being explored due to their structural similarity to natural tendon and their ability to promote tissue regeneration. This review discusses current methods of AT regeneration, recent advances in the fabrication and enhancement of nanofiber-based scaffolds, and the development and use of multiscale nanofiber-based scaffolds for AT regeneration.https://www.frontiersin.org/articles/10.3389/fbioe.2022.897010/fullregenerative engineeringAchilles tendonscaffoldsnanofibersnanofiber technology |
| spellingShingle | Senbo Zhu Senbo Zhu Zeju He Zeju He Lichen Ji Lichen Ji Wei Zhang Yu Tong Junchao Luo Junchao Luo Yin Zhang Yong Li Xiang Meng Qing Bi Qing Bi Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering Frontiers in Bioengineering and Biotechnology regenerative engineering Achilles tendon scaffolds nanofibers nanofiber technology |
| title | Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering |
| title_full | Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering |
| title_fullStr | Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering |
| title_full_unstemmed | Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering |
| title_short | Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering |
| title_sort | advanced nanofiber based scaffolds for achilles tendon regenerative engineering |
| topic | regenerative engineering Achilles tendon scaffolds nanofibers nanofiber technology |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.897010/full |
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