Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
Human pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16455-7 |
| _version_ | 1818991331401269248 |
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| author | Renata M. Martin Jonas L. Fowler M. Kyle Cromer Benjamin J. Lesch Ezequiel Ponce Nobuko Uchida Toshinobu Nishimura Matthew H. Porteus Kyle M. Loh |
| author_facet | Renata M. Martin Jonas L. Fowler M. Kyle Cromer Benjamin J. Lesch Ezequiel Ponce Nobuko Uchida Toshinobu Nishimura Matthew H. Porteus Kyle M. Loh |
| author_sort | Renata M. Martin |
| collection | DOAJ |
| description | Human pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types. |
| first_indexed | 2024-12-20T20:08:34Z |
| format | Article |
| id | doaj.art-1bf355be0de745bc987455ce3536745a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:08:34Z |
| publishDate | 2020-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1bf355be0de745bc987455ce3536745a2022-12-21T19:27:52ZengNature PortfolioNature Communications2041-17232020-06-0111111410.1038/s41467-020-16455-7Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguardsRenata M. Martin0Jonas L. Fowler1M. Kyle Cromer2Benjamin J. Lesch3Ezequiel Ponce4Nobuko Uchida5Toshinobu Nishimura6Matthew H. Porteus7Kyle M. Loh8Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of MedicineHuman pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types.https://doi.org/10.1038/s41467-020-16455-7 |
| spellingShingle | Renata M. Martin Jonas L. Fowler M. Kyle Cromer Benjamin J. Lesch Ezequiel Ponce Nobuko Uchida Toshinobu Nishimura Matthew H. Porteus Kyle M. Loh Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards Nature Communications |
| title | Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards |
| title_full | Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards |
| title_fullStr | Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards |
| title_full_unstemmed | Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards |
| title_short | Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards |
| title_sort | improving the safety of human pluripotent stem cell therapies using genome edited orthogonal safeguards |
| url | https://doi.org/10.1038/s41467-020-16455-7 |
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