Metaomics in Clinical Laboratory: Potential Driving Force for Innovative Disease Diagnosis
Currently, more and more studies suggested that reductionism was lack of holistic and integrative view of biological processes, leading to limited understanding of complex systems like microbiota and the associated diseases. In fact, microbes are rarely present in individuals but normally live in co...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.883734/full |
| _version_ | 1818252402724175872 |
|---|---|
| author | Liang Wang Fen Li Bin Gu Pengfei Qu Qinghua Liu Junjiao Wang Jiawei Tang Shubin Cai Qi Zhao Zhong Ming |
| author_facet | Liang Wang Fen Li Bin Gu Pengfei Qu Qinghua Liu Junjiao Wang Jiawei Tang Shubin Cai Qi Zhao Zhong Ming |
| author_sort | Liang Wang |
| collection | DOAJ |
| description | Currently, more and more studies suggested that reductionism was lack of holistic and integrative view of biological processes, leading to limited understanding of complex systems like microbiota and the associated diseases. In fact, microbes are rarely present in individuals but normally live in complex multispecies communities. With the recent development of a variety of metaomics techniques, microbes could be dissected dynamically in both temporal and spatial scales. Therefore, in-depth understanding of human microbiome from different aspects such as genomes, transcriptomes, proteomes, and metabolomes could provide novel insights into their functional roles, which also holds the potential in making them diagnostic biomarkers in many human diseases, though there is still a huge gap to fill for the purpose. In this mini-review, we went through the frontlines of the metaomics techniques and explored their potential applications in clinical diagnoses of human diseases, e.g., infectious diseases, through which we concluded that novel diagnostic methods based on human microbiomes shall be achieved in the near future, while the limitations of these techniques such as standard procedures and computational challenges for rapid and accurate analysis of metaomics data in clinical settings were also examined. |
| first_indexed | 2024-12-12T16:23:37Z |
| format | Article |
| id | doaj.art-1bf3b9ce345b446695a7c3751dc2324e |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T16:23:37Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-1bf3b9ce345b446695a7c3751dc2324e2022-12-22T00:18:55ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-06-011310.3389/fmicb.2022.883734883734Metaomics in Clinical Laboratory: Potential Driving Force for Innovative Disease DiagnosisLiang Wang0Fen Li1Bin Gu2Pengfei Qu3Qinghua Liu4Junjiao Wang5Jiawei Tang6Shubin Cai7Qi Zhao8Zhong Ming9Department of Bioinformatics, School of Medical Informatics and Engineering, Xuzhou Medical University, Xuzhou, ChinaDepartment of Laboratory Medicine, Huaiyin Hospital, Huai’an, ChinaDepartment of Bioinformatics, School of Medical Informatics and Engineering, Xuzhou Medical University, Xuzhou, ChinaThe First School of Clinical Medicine, Xuzhou Medical University, Xuzhou, ChinaState Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao SAR, ChinaDepartment of Bioinformatics, School of Medical Informatics and Engineering, Xuzhou Medical University, Xuzhou, ChinaDepartment of Bioinformatics, School of Medical Informatics and Engineering, Xuzhou Medical University, Xuzhou, ChinaCollege of Computer Science and Software Engineering, Shenzhen University, Shenzhen, ChinaSchool of Computer Science and Software Engineering, University of Science and Technology Liaoning, Anshan, ChinaCollege of Computer Science and Software Engineering, Shenzhen University, Shenzhen, ChinaCurrently, more and more studies suggested that reductionism was lack of holistic and integrative view of biological processes, leading to limited understanding of complex systems like microbiota and the associated diseases. In fact, microbes are rarely present in individuals but normally live in complex multispecies communities. With the recent development of a variety of metaomics techniques, microbes could be dissected dynamically in both temporal and spatial scales. Therefore, in-depth understanding of human microbiome from different aspects such as genomes, transcriptomes, proteomes, and metabolomes could provide novel insights into their functional roles, which also holds the potential in making them diagnostic biomarkers in many human diseases, though there is still a huge gap to fill for the purpose. In this mini-review, we went through the frontlines of the metaomics techniques and explored their potential applications in clinical diagnoses of human diseases, e.g., infectious diseases, through which we concluded that novel diagnostic methods based on human microbiomes shall be achieved in the near future, while the limitations of these techniques such as standard procedures and computational challenges for rapid and accurate analysis of metaomics data in clinical settings were also examined.https://www.frontiersin.org/articles/10.3389/fmicb.2022.883734/fullmicrobiologymicrobiomeomicsbiomarkerdiseasesrapid diagnosis |
| spellingShingle | Liang Wang Fen Li Bin Gu Pengfei Qu Qinghua Liu Junjiao Wang Jiawei Tang Shubin Cai Qi Zhao Zhong Ming Metaomics in Clinical Laboratory: Potential Driving Force for Innovative Disease Diagnosis Frontiers in Microbiology microbiology microbiome omics biomarker diseases rapid diagnosis |
| title | Metaomics in Clinical Laboratory: Potential Driving Force for Innovative Disease Diagnosis |
| title_full | Metaomics in Clinical Laboratory: Potential Driving Force for Innovative Disease Diagnosis |
| title_fullStr | Metaomics in Clinical Laboratory: Potential Driving Force for Innovative Disease Diagnosis |
| title_full_unstemmed | Metaomics in Clinical Laboratory: Potential Driving Force for Innovative Disease Diagnosis |
| title_short | Metaomics in Clinical Laboratory: Potential Driving Force for Innovative Disease Diagnosis |
| title_sort | metaomics in clinical laboratory potential driving force for innovative disease diagnosis |
| topic | microbiology microbiome omics biomarker diseases rapid diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.883734/full |
| work_keys_str_mv | AT liangwang metaomicsinclinicallaboratorypotentialdrivingforceforinnovativediseasediagnosis AT fenli metaomicsinclinicallaboratorypotentialdrivingforceforinnovativediseasediagnosis AT bingu metaomicsinclinicallaboratorypotentialdrivingforceforinnovativediseasediagnosis AT pengfeiqu metaomicsinclinicallaboratorypotentialdrivingforceforinnovativediseasediagnosis AT qinghualiu metaomicsinclinicallaboratorypotentialdrivingforceforinnovativediseasediagnosis AT junjiaowang metaomicsinclinicallaboratorypotentialdrivingforceforinnovativediseasediagnosis AT jiaweitang metaomicsinclinicallaboratorypotentialdrivingforceforinnovativediseasediagnosis AT shubincai metaomicsinclinicallaboratorypotentialdrivingforceforinnovativediseasediagnosis AT qizhao metaomicsinclinicallaboratorypotentialdrivingforceforinnovativediseasediagnosis AT zhongming metaomicsinclinicallaboratorypotentialdrivingforceforinnovativediseasediagnosis |