Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials
Introduction: The aim of this study is a comprehensive analysis of the parameters of exogenous evoked potentials (visual, brainstem auditory, and somatosensory) in patients with myasthenia gravis (MG), a prototype of both neuromuscular junction disease and autoimmune disease. The study also seeks to...
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MDPI AG
2021-08-01
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| Online Access: | https://www.mdpi.com/2076-3425/11/8/1057 |
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| author | Edyta Dziadkowiak Marta Waliszewska-Prosół Małgorzata Wieczorek Joanna Bladowska Sławomir Budrewicz Maria Ejma |
| author_facet | Edyta Dziadkowiak Marta Waliszewska-Prosół Małgorzata Wieczorek Joanna Bladowska Sławomir Budrewicz Maria Ejma |
| author_sort | Edyta Dziadkowiak |
| collection | DOAJ |
| description | Introduction: The aim of this study is a comprehensive analysis of the parameters of exogenous evoked potentials (visual, brainstem auditory, and somatosensory) in patients with myasthenia gravis (MG), a prototype of both neuromuscular junction disease and autoimmune disease. The study also seeks to isolate electrophysiological changes that may indicate disorders within the central and/or peripheral nervous system. Methods: A total of forty-two consecutive patients with myasthenia gravis (24 women, 18 men) were included in the study. All of the patients underwent EP examination. MR images were also analyzed. Results: In the group of MG patients, the latency of P100 (113.9 ± 13.9; <i>p</i> < 0.0001) VEP, wave III (3.92 ± 0.29; <i>p</i> = 0.015), wave V (5.93 ± 0.32; <0.0001), interlatency III–V (2.00 ± 0.12; <i>p</i> < 0.0001), interlatency I–V (4.20 ± 0.28; <i>p</i> < 0.001) BAEP, and all components of SEP (N9, P10, N13, P16, N20, P22) were significantly longer. Mean wave I and V amplitude BAEP were relatively lower. Conclusions: The results of the study suggest the presence of disturbances in the bioelectric activities of the central and peripheral nervous system in MG patients. |
| first_indexed | 2024-03-10T08:58:09Z |
| format | Article |
| id | doaj.art-1bf3e78985dc4b26b61f4df39b96636e |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T08:58:09Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-1bf3e78985dc4b26b61f4df39b96636e2023-11-22T06:59:29ZengMDPI AGBrain Sciences2076-34252021-08-01118105710.3390/brainsci11081057Myasthenia Gravis—An Analysis of Multimodal Evoked PotentialsEdyta Dziadkowiak0Marta Waliszewska-Prosół1Małgorzata Wieczorek2Joanna Bladowska3Sławomir Budrewicz4Maria Ejma5Department of Neurology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Neurology, Wroclaw Medical University, 50-556 Wroclaw, PolandFaculty of Earth Sciences and Environmental Management, University of Wroclaw, 50-137 Wroclaw, PolandDepartment of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Neurology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Neurology, Wroclaw Medical University, 50-556 Wroclaw, PolandIntroduction: The aim of this study is a comprehensive analysis of the parameters of exogenous evoked potentials (visual, brainstem auditory, and somatosensory) in patients with myasthenia gravis (MG), a prototype of both neuromuscular junction disease and autoimmune disease. The study also seeks to isolate electrophysiological changes that may indicate disorders within the central and/or peripheral nervous system. Methods: A total of forty-two consecutive patients with myasthenia gravis (24 women, 18 men) were included in the study. All of the patients underwent EP examination. MR images were also analyzed. Results: In the group of MG patients, the latency of P100 (113.9 ± 13.9; <i>p</i> < 0.0001) VEP, wave III (3.92 ± 0.29; <i>p</i> = 0.015), wave V (5.93 ± 0.32; <0.0001), interlatency III–V (2.00 ± 0.12; <i>p</i> < 0.0001), interlatency I–V (4.20 ± 0.28; <i>p</i> < 0.001) BAEP, and all components of SEP (N9, P10, N13, P16, N20, P22) were significantly longer. Mean wave I and V amplitude BAEP were relatively lower. Conclusions: The results of the study suggest the presence of disturbances in the bioelectric activities of the central and peripheral nervous system in MG patients.https://www.mdpi.com/2076-3425/11/8/1057myasthenia gravisvisual evoked potentialsbrainstem auditory evoked potentialssomatosensory evoked potentials |
| spellingShingle | Edyta Dziadkowiak Marta Waliszewska-Prosół Małgorzata Wieczorek Joanna Bladowska Sławomir Budrewicz Maria Ejma Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials Brain Sciences myasthenia gravis visual evoked potentials brainstem auditory evoked potentials somatosensory evoked potentials |
| title | Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials |
| title_full | Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials |
| title_fullStr | Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials |
| title_full_unstemmed | Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials |
| title_short | Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials |
| title_sort | myasthenia gravis an analysis of multimodal evoked potentials |
| topic | myasthenia gravis visual evoked potentials brainstem auditory evoked potentials somatosensory evoked potentials |
| url | https://www.mdpi.com/2076-3425/11/8/1057 |
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