Piezoelectrically induced augmented functionality of primary cultured hippocampal neurons on electrospun PVDF-(Na, K) NbO3 composite fibers
Owing to the risk of permanent disability of the associated tissue/organ, peripheral nerve injuries present one of the major concerns. As growth and regeneration of axons are sensitive towards electrical activity of substrate, polyvinylidene difluoride (PVDF)−10 vol% sodium potassium niobate (NKN) p...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Next Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949822823000709 |
| _version_ | 1797237736319483904 |
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| author | Deepak Khare Kei Nakayama Nobuyuki Shiina Kenichi Kakimoto Ashutosh Kumar Dubey |
| author_facet | Deepak Khare Kei Nakayama Nobuyuki Shiina Kenichi Kakimoto Ashutosh Kumar Dubey |
| author_sort | Deepak Khare |
| collection | DOAJ |
| description | Owing to the risk of permanent disability of the associated tissue/organ, peripheral nerve injuries present one of the major concerns. As growth and regeneration of axons are sensitive towards electrical activity of substrate, polyvinylidene difluoride (PVDF)−10 vol% sodium potassium niobate (NKN) piezoelectric composite fibers were electrospun and corona poled at 17 kV. Electrospun PVDF-NKN fibrous scaffolds show remarkable increase in the average number of dendrites per neuron and mean soma area of primary cultured hippocampal neurons of embryonic mice which further increases after polarization (∼ 1.3 and 1.6 times of unpoled PVDF, respectively). The developed composite can be suggested as a potential candidate for peripheral nerve regeneration. |
| first_indexed | 2024-04-24T17:24:29Z |
| format | Article |
| id | doaj.art-1bf44e11924641aebf9f744353130fbd |
| institution | Directory Open Access Journal |
| issn | 2949-8228 |
| language | English |
| last_indexed | 2024-04-24T17:24:29Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Next Materials |
| spelling | doaj.art-1bf44e11924641aebf9f744353130fbd2024-03-28T06:41:12ZengElsevierNext Materials2949-82282024-01-012100070Piezoelectrically induced augmented functionality of primary cultured hippocampal neurons on electrospun PVDF-(Na, K) NbO3 composite fibersDeepak Khare0Kei Nakayama1Nobuyuki Shiina2Kenichi Kakimoto3Ashutosh Kumar Dubey4Department of Ceramic Engineering, Indian Institute of Technology (BHU) Varanasi, 221005, IndiaLaboratory of Neuronal Cell Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan; Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki, Aichi 444-8585, Japan; Department of Basic Biology, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8585, JapanLaboratory of Neuronal Cell Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan; Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki, Aichi 444-8585, Japan; Department of Basic Biology, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8585, JapanDepartment of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-Cho, Showa-Ku, Nagoya 466-8555, JapanDepartment of Ceramic Engineering, Indian Institute of Technology (BHU) Varanasi, 221005, India; Corresponding author.Owing to the risk of permanent disability of the associated tissue/organ, peripheral nerve injuries present one of the major concerns. As growth and regeneration of axons are sensitive towards electrical activity of substrate, polyvinylidene difluoride (PVDF)−10 vol% sodium potassium niobate (NKN) piezoelectric composite fibers were electrospun and corona poled at 17 kV. Electrospun PVDF-NKN fibrous scaffolds show remarkable increase in the average number of dendrites per neuron and mean soma area of primary cultured hippocampal neurons of embryonic mice which further increases after polarization (∼ 1.3 and 1.6 times of unpoled PVDF, respectively). The developed composite can be suggested as a potential candidate for peripheral nerve regeneration.http://www.sciencedirect.com/science/article/pii/S2949822823000709BiocompositeElectrospinningSurface propertiesMicrostructures |
| spellingShingle | Deepak Khare Kei Nakayama Nobuyuki Shiina Kenichi Kakimoto Ashutosh Kumar Dubey Piezoelectrically induced augmented functionality of primary cultured hippocampal neurons on electrospun PVDF-(Na, K) NbO3 composite fibers Next Materials Biocomposite Electrospinning Surface properties Microstructures |
| title | Piezoelectrically induced augmented functionality of primary cultured hippocampal neurons on electrospun PVDF-(Na, K) NbO3 composite fibers |
| title_full | Piezoelectrically induced augmented functionality of primary cultured hippocampal neurons on electrospun PVDF-(Na, K) NbO3 composite fibers |
| title_fullStr | Piezoelectrically induced augmented functionality of primary cultured hippocampal neurons on electrospun PVDF-(Na, K) NbO3 composite fibers |
| title_full_unstemmed | Piezoelectrically induced augmented functionality of primary cultured hippocampal neurons on electrospun PVDF-(Na, K) NbO3 composite fibers |
| title_short | Piezoelectrically induced augmented functionality of primary cultured hippocampal neurons on electrospun PVDF-(Na, K) NbO3 composite fibers |
| title_sort | piezoelectrically induced augmented functionality of primary cultured hippocampal neurons on electrospun pvdf na k nbo3 composite fibers |
| topic | Biocomposite Electrospinning Surface properties Microstructures |
| url | http://www.sciencedirect.com/science/article/pii/S2949822823000709 |
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