Developmental and Early Life Origins of Hypertension: Preventive Aspects of Melatonin
Hypertension represents a major disease burden worldwide. Abundant evidence suggests that hypertension can originate in early life. Adverse programming processes can be prevented by early life intervention—namely, reprogramming—to avoid developing chronic diseases later in life. Melatonin is an endo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/5/924 |
| _version_ | 1827670650594000896 |
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| author | You-Lin Tain Chien-Ning Hsu |
| author_facet | You-Lin Tain Chien-Ning Hsu |
| author_sort | You-Lin Tain |
| collection | DOAJ |
| description | Hypertension represents a major disease burden worldwide. Abundant evidence suggests that hypertension can originate in early life. Adverse programming processes can be prevented by early life intervention—namely, reprogramming—to avoid developing chronic diseases later in life. Melatonin is an endogenously produced hormone with a multifaceted biological function. Although melatonin supplementation has shown benefits for human health, less attention has been paid to exploring its reprogramming effects on the early life origins of hypertension. In this review, first, we discuss the physiological roles of melatonin in pregnancy, fetal development, and the regulation of blood pressure. Then, we summarize the epidemiological and experimental evidence for the early life origins of hypertension. This is followed by a description of the animal models used to examine early melatonin therapy as a reprogramming strategy to protect against the early life origins of hypertension. A deeper understanding of the developmental programming of hypertension and recent advances in early melatonin intervention might provide a path forward in reducing the global burden of hypertension. |
| first_indexed | 2024-03-10T03:26:03Z |
| format | Article |
| id | doaj.art-1bf5c3f6951a446da690c5344ce50ec9 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T03:26:03Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1bf5c3f6951a446da690c5344ce50ec92023-11-23T09:51:47ZengMDPI AGAntioxidants2076-39212022-05-0111592410.3390/antiox11050924Developmental and Early Life Origins of Hypertension: Preventive Aspects of MelatoninYou-Lin Tain0Chien-Ning Hsu1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanHypertension represents a major disease burden worldwide. Abundant evidence suggests that hypertension can originate in early life. Adverse programming processes can be prevented by early life intervention—namely, reprogramming—to avoid developing chronic diseases later in life. Melatonin is an endogenously produced hormone with a multifaceted biological function. Although melatonin supplementation has shown benefits for human health, less attention has been paid to exploring its reprogramming effects on the early life origins of hypertension. In this review, first, we discuss the physiological roles of melatonin in pregnancy, fetal development, and the regulation of blood pressure. Then, we summarize the epidemiological and experimental evidence for the early life origins of hypertension. This is followed by a description of the animal models used to examine early melatonin therapy as a reprogramming strategy to protect against the early life origins of hypertension. A deeper understanding of the developmental programming of hypertension and recent advances in early melatonin intervention might provide a path forward in reducing the global burden of hypertension.https://www.mdpi.com/2076-3921/11/5/924developmental origins of health and disease (DOHaD)glucocorticoidgut microbiotamelatoninhypertensionrenin–angiotensin system |
| spellingShingle | You-Lin Tain Chien-Ning Hsu Developmental and Early Life Origins of Hypertension: Preventive Aspects of Melatonin Antioxidants developmental origins of health and disease (DOHaD) glucocorticoid gut microbiota melatonin hypertension renin–angiotensin system |
| title | Developmental and Early Life Origins of Hypertension: Preventive Aspects of Melatonin |
| title_full | Developmental and Early Life Origins of Hypertension: Preventive Aspects of Melatonin |
| title_fullStr | Developmental and Early Life Origins of Hypertension: Preventive Aspects of Melatonin |
| title_full_unstemmed | Developmental and Early Life Origins of Hypertension: Preventive Aspects of Melatonin |
| title_short | Developmental and Early Life Origins of Hypertension: Preventive Aspects of Melatonin |
| title_sort | developmental and early life origins of hypertension preventive aspects of melatonin |
| topic | developmental origins of health and disease (DOHaD) glucocorticoid gut microbiota melatonin hypertension renin–angiotensin system |
| url | https://www.mdpi.com/2076-3921/11/5/924 |
| work_keys_str_mv | AT youlintain developmentalandearlylifeoriginsofhypertensionpreventiveaspectsofmelatonin AT chienninghsu developmentalandearlylifeoriginsofhypertensionpreventiveaspectsofmelatonin |