Increased number of neural progenitors in human temporal lobe epilepsy
An increased neurogenesis is reported in animal models of mesial temporal lobe epilepsy (MTLE) but the fate of newborn cells is unknown. Here, we attempted to demonstrate neurogenesis in adult epileptic tissue obtained after hippocampectomy. MTLE hippocampi showed increased expression of division ma...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2005-08-01
|
| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996105000355 |
| _version_ | 1819161078622322688 |
|---|---|
| author | Arielle Crespel Valérie Rigau Philippe Coubes Marie Claude Rousset Frédéric de Bock Hideyuki Okano Michel Baldy-Moulinier Joël Bockaert Mireille Lerner-Natoli |
| author_facet | Arielle Crespel Valérie Rigau Philippe Coubes Marie Claude Rousset Frédéric de Bock Hideyuki Okano Michel Baldy-Moulinier Joël Bockaert Mireille Lerner-Natoli |
| author_sort | Arielle Crespel |
| collection | DOAJ |
| description | An increased neurogenesis is reported in animal models of mesial temporal lobe epilepsy (MTLE) but the fate of newborn cells is unknown. Here, we attempted to demonstrate neurogenesis in adult epileptic tissue obtained after hippocampectomy. MTLE hippocampi showed increased expression of division markers and of Musashi-1, a marker of neural progenitors, compared to control hippocampi. Large quantities of Musashi-1+ cells were obvious in the subgranular layer and the subventricular zone, both known neurogenic areas, and in the fissura hippocampi. Musashi-1 was expressed by small cells that were mainly vimentin+ or nestin+, rarely Dcx+ or PSA-NCAM+ and negative for markers of mature neurons or astrocytes. Some of them are present in the granular layer, the hilus, and CA1 area resembling the ectopic positions described in rodents. These findings demonstrate that neural progenitors proliferate in chronic epilepsy and suggest that the fissura hippocampi behaves like another neurogenic area. |
| first_indexed | 2024-12-22T17:06:38Z |
| format | Article |
| id | doaj.art-1bf7be2d1dee4221be900e7a19ef5cfd |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-22T17:06:38Z |
| publishDate | 2005-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-1bf7be2d1dee4221be900e7a19ef5cfd2022-12-21T18:19:10ZengElsevierNeurobiology of Disease1095-953X2005-08-01193436450Increased number of neural progenitors in human temporal lobe epilepsyArielle Crespel0Valérie Rigau1Philippe Coubes2Marie Claude Rousset3Frédéric de Bock4Hideyuki Okano5Michel Baldy-Moulinier6Joël Bockaert7Mireille Lerner-Natoli8Institut de Génomique Fonctionnelle, CNRS UMR 5023-INSERM U661, UM1-UM2, 141 rue de la Cardonille, F-34094 Montpellier Cedex 5, France; Unité Médico-chirurgicale de l'Epilepsie, Hôpital Gui de Chauliac, 80 av Fliche, 34295 Montpellier Cedex 05, FranceInstitut de Génomique Fonctionnelle, CNRS UMR 5023-INSERM U661, UM1-UM2, 141 rue de la Cardonille, F-34094 Montpellier Cedex 5, France; Service d'Anatomopathologie, Hôpital Gui de Chauliac, 80 av Fliche, 34295 Montpellier Cedex 05, FranceUnité Médico-chirurgicale de l'Epilepsie, Hôpital Gui de Chauliac, 80 av Fliche, 34295 Montpellier Cedex 05, FranceInstitut de Génomique Fonctionnelle, CNRS UMR 5023-INSERM U661, UM1-UM2, 141 rue de la Cardonille, F-34094 Montpellier Cedex 5, FranceInstitut de Génomique Fonctionnelle, CNRS UMR 5023-INSERM U661, UM1-UM2, 141 rue de la Cardonille, F-34094 Montpellier Cedex 5, FranceDepartment of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanInstitut de Génomique Fonctionnelle, CNRS UMR 5023-INSERM U661, UM1-UM2, 141 rue de la Cardonille, F-34094 Montpellier Cedex 5, France; Unité Médico-chirurgicale de l'Epilepsie, Hôpital Gui de Chauliac, 80 av Fliche, 34295 Montpellier Cedex 05, FranceInstitut de Génomique Fonctionnelle, CNRS UMR 5023-INSERM U661, UM1-UM2, 141 rue de la Cardonille, F-34094 Montpellier Cedex 5, FranceInstitut de Génomique Fonctionnelle, CNRS UMR 5023-INSERM U661, UM1-UM2, 141 rue de la Cardonille, F-34094 Montpellier Cedex 5, France; Corresponding author. Fax: +33 4 67 54 24 32.An increased neurogenesis is reported in animal models of mesial temporal lobe epilepsy (MTLE) but the fate of newborn cells is unknown. Here, we attempted to demonstrate neurogenesis in adult epileptic tissue obtained after hippocampectomy. MTLE hippocampi showed increased expression of division markers and of Musashi-1, a marker of neural progenitors, compared to control hippocampi. Large quantities of Musashi-1+ cells were obvious in the subgranular layer and the subventricular zone, both known neurogenic areas, and in the fissura hippocampi. Musashi-1 was expressed by small cells that were mainly vimentin+ or nestin+, rarely Dcx+ or PSA-NCAM+ and negative for markers of mature neurons or astrocytes. Some of them are present in the granular layer, the hilus, and CA1 area resembling the ectopic positions described in rodents. These findings demonstrate that neural progenitors proliferate in chronic epilepsy and suggest that the fissura hippocampi behaves like another neurogenic area.http://www.sciencedirect.com/science/article/pii/S0969996105000355Temporal lobe epilepsyHumanHippocampusNeurogenesisProgenitorsMusashi-1 |
| spellingShingle | Arielle Crespel Valérie Rigau Philippe Coubes Marie Claude Rousset Frédéric de Bock Hideyuki Okano Michel Baldy-Moulinier Joël Bockaert Mireille Lerner-Natoli Increased number of neural progenitors in human temporal lobe epilepsy Neurobiology of Disease Temporal lobe epilepsy Human Hippocampus Neurogenesis Progenitors Musashi-1 |
| title | Increased number of neural progenitors in human temporal lobe epilepsy |
| title_full | Increased number of neural progenitors in human temporal lobe epilepsy |
| title_fullStr | Increased number of neural progenitors in human temporal lobe epilepsy |
| title_full_unstemmed | Increased number of neural progenitors in human temporal lobe epilepsy |
| title_short | Increased number of neural progenitors in human temporal lobe epilepsy |
| title_sort | increased number of neural progenitors in human temporal lobe epilepsy |
| topic | Temporal lobe epilepsy Human Hippocampus Neurogenesis Progenitors Musashi-1 |
| url | http://www.sciencedirect.com/science/article/pii/S0969996105000355 |
| work_keys_str_mv | AT ariellecrespel increasednumberofneuralprogenitorsinhumantemporallobeepilepsy AT valerierigau increasednumberofneuralprogenitorsinhumantemporallobeepilepsy AT philippecoubes increasednumberofneuralprogenitorsinhumantemporallobeepilepsy AT marieclauderousset increasednumberofneuralprogenitorsinhumantemporallobeepilepsy AT fredericdebock increasednumberofneuralprogenitorsinhumantemporallobeepilepsy AT hideyukiokano increasednumberofneuralprogenitorsinhumantemporallobeepilepsy AT michelbaldymoulinier increasednumberofneuralprogenitorsinhumantemporallobeepilepsy AT joelbockaert increasednumberofneuralprogenitorsinhumantemporallobeepilepsy AT mireillelernernatoli increasednumberofneuralprogenitorsinhumantemporallobeepilepsy |