Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation
A Simple, rapid and sensitive extractive and spectrophotometric method has been described for the analysis of diphenhyldramine –HCl (DPH) in pure form and in pharmaceutical formulations. The method is based on the formation of chloroform soluble ion-pair complex with Bromophenol blue(BPB) in...
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| Format: | Article |
| Language: | English |
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University of Baghdad
2016-12-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| Subjects: | |
| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/864 |
| _version_ | 1817982476604145664 |
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| author | A. K. Mohammed S. B. Dikran M. Abdul Sattar Alubydi |
| author_facet | A. K. Mohammed S. B. Dikran M. Abdul Sattar Alubydi |
| author_sort | A. K. Mohammed |
| collection | DOAJ |
| description |
A Simple, rapid and sensitive extractive and spectrophotometric method has been described for the analysis of diphenhyldramine –HCl (DPH) in pure form and in pharmaceutical formulations. The method is based on the formation of chloroform soluble ion-pair complex with Bromophenol blue(BPB) in a phthalate buffer at pH 3.0.The extracted complex shows maximum absorbance at 410 nm. Beer's law is obeyed in the concentration range 0.2-25.0 µg.ml-1. The molar absorptivity and Sandell's sensitivity for the system being 2.416x104 L.mol-1.cm-1 and 0.012µg.cm-2, respectively. The limit of detection was found to be 0.155 µg.ml-1. The proposed method was successfully applied to the determination of the drug in pharmaceutical formulation and satisfactory results were obtained.
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| first_indexed | 2024-04-13T23:21:18Z |
| format | Article |
| id | doaj.art-1bf898e2e64c4482937bc38b0de4898f |
| institution | Directory Open Access Journal |
| issn | 1609-4042 2521-3407 |
| language | English |
| last_indexed | 2024-04-13T23:21:18Z |
| publishDate | 2016-12-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj.art-1bf898e2e64c4482937bc38b0de4898f2022-12-22T02:25:14ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072016-12-01241Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair FormationA. K. MohammedS. B. DikranM. Abdul Sattar Alubydi A Simple, rapid and sensitive extractive and spectrophotometric method has been described for the analysis of diphenhyldramine –HCl (DPH) in pure form and in pharmaceutical formulations. The method is based on the formation of chloroform soluble ion-pair complex with Bromophenol blue(BPB) in a phthalate buffer at pH 3.0.The extracted complex shows maximum absorbance at 410 nm. Beer's law is obeyed in the concentration range 0.2-25.0 µg.ml-1. The molar absorptivity and Sandell's sensitivity for the system being 2.416x104 L.mol-1.cm-1 and 0.012µg.cm-2, respectively. The limit of detection was found to be 0.155 µg.ml-1. The proposed method was successfully applied to the determination of the drug in pharmaceutical formulation and satisfactory results were obtained. https://jih.uobaghdad.edu.iq/index.php/j/article/view/864The Analysis of Diphenhydramine-HCl Through Ion-pair Formation, Univariate and Simplex Optimization |
| spellingShingle | A. K. Mohammed S. B. Dikran M. Abdul Sattar Alubydi Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation Ibn Al-Haitham Journal for Pure and Applied Sciences The Analysis of Diphenhydramine-HCl Through Ion-pair Formation, Univariate and Simplex Optimization |
| title | Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation |
| title_full | Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation |
| title_fullStr | Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation |
| title_full_unstemmed | Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation |
| title_short | Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation |
| title_sort | univariate and simplex optimization for the analysis of diphenhydramine hcl through ion pair formation |
| topic | The Analysis of Diphenhydramine-HCl Through Ion-pair Formation, Univariate and Simplex Optimization |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/864 |
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