Antihypertensives’ Rock around the Clock
Although homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable and that variability occurs in cycles. In order to explain and understand dysregulation, which has not been embraced by homeostatic principles, the allostatic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | J |
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| Online Access: | https://www.mdpi.com/2571-8800/4/1/5 |
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| author | Ognjenka Rahić Amina Tucak Merima Sirbubalo Lamija Hindija Jasmina Hadžiabdić |
| author_facet | Ognjenka Rahić Amina Tucak Merima Sirbubalo Lamija Hindija Jasmina Hadžiabdić |
| author_sort | Ognjenka Rahić |
| collection | DOAJ |
| description | Although homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable and that variability occurs in cycles. In order to explain and understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model has emerged as the first serious challenge to homeostasis, going beyond its homeostatic roots. Circadian rhythm is the predominant variation in the body, and it is a pattern according to which many physiological and pathological events occur. As there is strong experimental and clinical evidence that blood pressure fluctuations undergo circadian rhythm, there is equally strong evidence that targeted time therapy for hypertension provides a better outcome of the disease. The research has gone even further throughout the development and approval process for the use of pulsatile drug release systems, which can be considered as an option for an even more convenient dosage regimen of the medicines needed. |
| first_indexed | 2024-03-10T13:05:29Z |
| format | Article |
| id | doaj.art-1bf8efd8a397408d9b6882222fc76760 |
| institution | Directory Open Access Journal |
| issn | 2571-8800 |
| language | English |
| last_indexed | 2024-03-10T13:05:29Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | J |
| spelling | doaj.art-1bf8efd8a397408d9b6882222fc767602023-11-21T11:06:13ZengMDPI AGJ2571-88002021-03-0141628110.3390/j4010005Antihypertensives’ Rock around the ClockOgnjenka Rahić0Amina Tucak1Merima Sirbubalo2Lamija Hindija3Jasmina Hadžiabdić4Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaAlthough homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable and that variability occurs in cycles. In order to explain and understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model has emerged as the first serious challenge to homeostasis, going beyond its homeostatic roots. Circadian rhythm is the predominant variation in the body, and it is a pattern according to which many physiological and pathological events occur. As there is strong experimental and clinical evidence that blood pressure fluctuations undergo circadian rhythm, there is equally strong evidence that targeted time therapy for hypertension provides a better outcome of the disease. The research has gone even further throughout the development and approval process for the use of pulsatile drug release systems, which can be considered as an option for an even more convenient dosage regimen of the medicines needed.https://www.mdpi.com/2571-8800/4/1/5hypertensionallostasischronotherapypulsatile drug release |
| spellingShingle | Ognjenka Rahić Amina Tucak Merima Sirbubalo Lamija Hindija Jasmina Hadžiabdić Antihypertensives’ Rock around the Clock J hypertension allostasis chronotherapy pulsatile drug release |
| title | Antihypertensives’ Rock around the Clock |
| title_full | Antihypertensives’ Rock around the Clock |
| title_fullStr | Antihypertensives’ Rock around the Clock |
| title_full_unstemmed | Antihypertensives’ Rock around the Clock |
| title_short | Antihypertensives’ Rock around the Clock |
| title_sort | antihypertensives rock around the clock |
| topic | hypertension allostasis chronotherapy pulsatile drug release |
| url | https://www.mdpi.com/2571-8800/4/1/5 |
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