Hyperglycemia aggravates ischemic brain damage via ERK1/2 activated cell autophagy and mitochondrial fission

Hyperglycemia aggravates ischemic brain damage via ERK1/2 activated cell autophagy and mitochondrial fission

BackgroundHyperglycemia is one of the major risk factors for stroke and stroke recurrence, leading to aggravated neuronal damage after cerebral ischemia/reperfusion (I/R). ERK1/2 signaling pathway plays a vital role in cerebral ischemic injury. However, the role of the ERK1/2 pathway in hyperglycemi...

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Bibliographic Details
Main Authors: Ping Liu, Xiao Yang, Jianguo Niu, Changchun Hei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Endocrinology
Subjects:
hyperglycemia
cerebral ischemic injury
ERK1/2
Drp-1
mitochondrial fission
cell autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.928591/full

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