Activation of RIG-I-Mediated Antiviral Signaling Triggers Autophagy Through the MAVS-TRAF6-Beclin-1 Signaling Axis

Activation of RIG-I-Mediated Antiviral Signaling Triggers Autophagy Through the MAVS-TRAF6-Beclin-1 Signaling Axis

Autophagy has been implicated in innate immune responses against various intracellular pathogens. Recent studies have reported that autophagy can be triggered by pathogen recognizing sensors, including Toll-like receptors and cyclic guanosine monophosphate-adenosine monophosphate synthase, to partic...

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Bibliographic Details
Main Authors: Na-Rae Lee, Junsu Ban, Noh-Jin Lee, Chae-Min Yi, Ji-Yoon Choi, Hyunbin Kim, Jong Kil Lee, Jihye Seong, Nam-Hyuk Cho, Jae U. Jung, Kyung-Soo Inn
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
autophagy
RIG-I
MAVS
TRAF6
polyubiquitination
Beclin-1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02096/full

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