Adventures and Advances in Time Travel With Induced Pluripotent Stem Cells and Automated Patch Clamp

Adventures and Advances in Time Travel With Induced Pluripotent Stem Cells and Automated Patch Clamp

In the Hollywood blockbuster “The Curious Case of Benjamin Button” a fantastical fable unfolds of a man’s life that travels through time reversing the aging process; as the tale progresses, the frail old man becomes a vigorous, vivacious young man, then man becomes boy and boy becomes baby. The real...

Full description

Bibliographic Details
Main Authors:	Kadla R. Rosholm, Beatrice Badone, Stefania Karatsiompani, David Nagy, Fitzwilliam Seibertz, Niels Voigt, Damian C. Bell
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	hiPSC stem cells automated patch clamp cardiomyocytes neurons ion channels
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2022.898717/full

Similar Items

Recording ten-fold larger IKr conductances with automated patch clamping using equimolar Cs+ solutions
by: Meye Bloothooft, et al.
Published: (2024-01-01)

There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments
by: Markus Rapedius, et al.
Published: (2022-08-01)

Activation of AMPK Promotes Maturation of Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
by: Liang Ye, et al.
Published: (2021-03-01)

Single‐Cell Patch‐Clamp/Proteomics of Human Alzheimer's Disease iPSC‐Derived Excitatory Neurons Versus Isogenic Wild‐Type Controls Suggests Novel Causation and Therapeutic Targets
by: Swagata Ghatak, et al.
Published: (2024-08-01)

Effect and mechanism of T lymphocytes on human induced pluripotent stem cell-derived cardiomyocytes via Proteomics
by: Jin Ye, et al.
Published: (2024-07-01)

Harnessing the potential of human induced pluripotent stem cells, functional assays and machine learning for neurodevelopmental disorders
by: Ziqin Yang, et al.
Published: (2025-01-01)

Acute effects of cardiac contractility modulation on human induced pluripotent stem cell–derived cardiomyocytes
by: Tromondae K. Feaster, et al.
Published: (2021-11-01)

Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells
by: Augustine, George James, et al.
Published: (2017)

Uninterrupted monitoring of drug effects in human-induced pluripotent stem cell-derived cardiomyocytes with bioluminescence Ca2+ microscopy
by: Kazushi Suzuki, et al.
Published: (2018-05-01)

Incomplete Assembly of the Dystrophin-Associated Protein Complex in 2D and 3D-Cultured Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
by: Guillaume Gilbert, et al.
Published: (2021-11-01)

ELM2‐SANT Domain‐Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human‐Induced Pluripotent Stem Cells
by: Yu‐An Lu, et al.
Published: (2024-07-01)

Retinoic acid modulation guides human-induced pluripotent stem cell differentiation towards left or right ventricle-like cardiomyocytes
by: Hengliang Zhang, et al.
Published: (2024-06-01)

Regulation of APD and Force by the Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Human-Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue
by: Djemail Ismaili, et al.
Published: (2022-08-01)

PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes
by: Huiwen Liu, et al.
Published: (2023-09-01)

Transcriptomics reveal stretched human pluripotent stem cell-derived cardiomyocytes as an advantageous hypertrophy model
by: Lotta Pohjolainen, et al.
Published: (2022-12-01)

Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes
by: Yvonne Sleiman, et al.
Published: (2020-10-01)

Development of a high-speed imaging system for real time evaluation and monitoring of cardiac engineered tissues
by: Antoine Belzil, et al.
Published: (2024-08-01)

Editorial: Recent advances in cardiotoxicity testing, volume II
by: Abou-Bakr M. Salama, et al.
Published: (2024-04-01)

Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy
by: Monia Souidi, et al.
Published: (2024-04-01)

Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes
by: Christian Zuppinger, et al.
Published: (2017-06-01)

Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters
by: Duncan C. Miller, et al.
Published: (2017-12-01)

Deciphering Common Long QT Syndrome Using CRISPR/Cas9 in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
by: Yongfei Song, et al.
Published: (2022-05-01)

Automated image analysis system for studying cardiotoxicity in human pluripotent stem cell-Derived cardiomyocytes
by: Lu Cao, et al.
Published: (2020-05-01)

Induced pluripotent stem cell-based models: Are we ready for that heart in a dish?
by: Irene Bissoli, et al.
Published: (2023-01-01)

Immune response caused by M1 macrophages elicits atrial fibrillation-like phenotypes in coculture model with isogenic hiPSC-derived cardiomyocytes
by: Thomas Hutschalik, et al.
Published: (2024-09-01)

Toward a Microencapsulated 3D hiPSC-Derived in vitro Cardiac Microtissue for Recapitulation of Human Heart Microenvironment Features
by: Bernardo Abecasis, et al.
Published: (2020-11-01)

Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells
by: Abinaya Chandrasekaran, et al.
Published: (2017-12-01)

Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation
by: Homa Hamledari, et al.
Published: (2022-08-01)

Replacement of Mouse Microglia With Human Induced Pluripotent Stem Cell (hiPSC)-Derived Microglia in Mouse Organotypic Slice Cultures
by: Ari Ogaki, et al.
Published: (2022-07-01)

A distribution analysis of action potential parameters obtained from patch-clamped human stem cell-derived cardiomyocytes
by: Fernando López-Redondo, et al.
Published: (2016-06-01)

Evidence of Adult Features and Functions of Hepatocytes Differentiated from Human Induced Pluripotent Stem Cells and Self-Organized as Organoids
by: Antonietta Messina, et al.
Published: (2022-02-01)

Expression of Extracellular Vesicle PIWI-Interacting RNAs Throughout hiPSC-Cardiomyocyte Differentiation
by: Ana F. Louro, et al.
Published: (2022-06-01)

Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
by: Lotta Pohjolainen, et al.
Published: (2021-01-01)

A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes
by: Fitzwilliam Seibertz, et al.
Published: (2022-09-01)

Modeling of Fabry disease nephropathy using patient derived human induced pluripotent stem cells and kidney organoid system
by: Sheng Cui, et al.
Published: (2023-02-01)

Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Predict the Cardiotoxicity Potential of Next Generation Nicotine Products
by: Liam Simms, et al.
Published: (2022-02-01)

Generation of two induced pluripotent stem cell lines from hereditary amyloidosis patients with polyneuropathy carrying heterozygous transthyretin (TTR) mutation
by: Juan Melesio, et al.
Published: (2024-02-01)

Synaptic disruption and CREB‐regulated transcription are restored by K+ channel blockers in ALS
by: Alberto Catanese, et al.
Published: (2021-06-01)

Differentiation of Glial Cells From hiPSCs: Potential Applications in Neurological Diseases and Cell Replacement Therapy
by: Wei Zheng, et al.
Published: (2018-08-01)

Clozapine Reverses Dysfunction of Glutamatergic Neurons Derived From Clozapine-Responsive Schizophrenia Patients
by: Hana Hribkova, et al.
Published: (2022-02-01)