Case-control study of relationship of infection by respiratory viruses with acute otitis media in Chinese children
Background: Acute otitis media (AOM) may occur as a complication of viral upper respiratory infection (URI) in children. Our objective was to examine children with URI + AOM or URI alone to determine the association of infection by different common respiratory viruses with AOM. Methods: Nasopharynge...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023016298 |
| _version_ | 1797851762182324224 |
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| author | Yue Fan Dongdong Li Pu Wang Lili Ren Xiaowei Chen |
| author_facet | Yue Fan Dongdong Li Pu Wang Lili Ren Xiaowei Chen |
| author_sort | Yue Fan |
| collection | DOAJ |
| description | Background: Acute otitis media (AOM) may occur as a complication of viral upper respiratory infection (URI) in children. Our objective was to examine children with URI + AOM or URI alone to determine the association of infection by different common respiratory viruses with AOM. Methods: Nasopharyngeal swabs were collected from March 2014 to February 2015. Quantitative PCR was then used to identify the following 10 common respiratory viruses: respiratory syncytial virus (RSV); parainfluenza viruses 1–4 (PIVs); influenza virus type A (IFVA); influenza virus type B; human rhinovirus (HRV); enterovirus; human metapneumovirus; human coronavirus OC43, 229E, NL63, and HKU1; adenovirus; and human bocavirus. Results: We examined 255 children with URIs (mean age: 32.9 ± 18.7 months), and 164 (64.1%) of them tested positive for at least one respiratory virus. The most common viruses were RSV (44, 24.3%), PIVs (28, 15.5%), and IFVA (25, 13.8%). Positivity for RSV was significantly greater in the URI + AOM group than in the URI group, but these groups did not differ in infection rates for the other 9 viruses. There were also significant seasonal differences in positivity for RSV, IFVA, HRV,HBoV, PIVs and EV. Conclusion: Our results indicated a relationship between infection by common respiratory viruses and AOM in children from Beijing. A URI with RSV significantly increased the risk of AOM in these children. |
| first_indexed | 2024-04-09T19:23:05Z |
| format | Article |
| id | doaj.art-1bff39e4f09a415a83cc7de97341ac74 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:23:05Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-1bff39e4f09a415a83cc7de97341ac742023-04-05T08:25:25ZengElsevierHeliyon2405-84402023-03-0193e14422Case-control study of relationship of infection by respiratory viruses with acute otitis media in Chinese childrenYue Fan0Dongdong Li1Pu Wang2Lili Ren3Xiaowei Chen4Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing, Beijing, 100730, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xin Jiang Karamay Central Hospital, 834000, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, ChinaNational Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Corresponding author. Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China; Corresponding author.Background: Acute otitis media (AOM) may occur as a complication of viral upper respiratory infection (URI) in children. Our objective was to examine children with URI + AOM or URI alone to determine the association of infection by different common respiratory viruses with AOM. Methods: Nasopharyngeal swabs were collected from March 2014 to February 2015. Quantitative PCR was then used to identify the following 10 common respiratory viruses: respiratory syncytial virus (RSV); parainfluenza viruses 1–4 (PIVs); influenza virus type A (IFVA); influenza virus type B; human rhinovirus (HRV); enterovirus; human metapneumovirus; human coronavirus OC43, 229E, NL63, and HKU1; adenovirus; and human bocavirus. Results: We examined 255 children with URIs (mean age: 32.9 ± 18.7 months), and 164 (64.1%) of them tested positive for at least one respiratory virus. The most common viruses were RSV (44, 24.3%), PIVs (28, 15.5%), and IFVA (25, 13.8%). Positivity for RSV was significantly greater in the URI + AOM group than in the URI group, but these groups did not differ in infection rates for the other 9 viruses. There were also significant seasonal differences in positivity for RSV, IFVA, HRV,HBoV, PIVs and EV. Conclusion: Our results indicated a relationship between infection by common respiratory viruses and AOM in children from Beijing. A URI with RSV significantly increased the risk of AOM in these children.http://www.sciencedirect.com/science/article/pii/S2405844023016298Acute otitis mediaUpper respiratory infectionVirusRespiratory syncytial virus |
| spellingShingle | Yue Fan Dongdong Li Pu Wang Lili Ren Xiaowei Chen Case-control study of relationship of infection by respiratory viruses with acute otitis media in Chinese children Heliyon Acute otitis media Upper respiratory infection Virus Respiratory syncytial virus |
| title | Case-control study of relationship of infection by respiratory viruses with acute otitis media in Chinese children |
| title_full | Case-control study of relationship of infection by respiratory viruses with acute otitis media in Chinese children |
| title_fullStr | Case-control study of relationship of infection by respiratory viruses with acute otitis media in Chinese children |
| title_full_unstemmed | Case-control study of relationship of infection by respiratory viruses with acute otitis media in Chinese children |
| title_short | Case-control study of relationship of infection by respiratory viruses with acute otitis media in Chinese children |
| title_sort | case control study of relationship of infection by respiratory viruses with acute otitis media in chinese children |
| topic | Acute otitis media Upper respiratory infection Virus Respiratory syncytial virus |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023016298 |
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