Antimicrobial Peptides in Infectious Diseases and Beyond—A Narrative Review
Despite recent medical research and clinical practice developments, the development of antimicrobial resistance (AMR) significantly limits therapeutics for infectious diseases. Thus, novel treatments for infectious diseases, especially in this era of increasing AMR, are urgently needed. There is ong...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/8/1651 |
| _version_ | 1827729390352465920 |
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| author | Petros Ioannou Stella Baliou Diamantis P. Kofteridis |
| author_facet | Petros Ioannou Stella Baliou Diamantis P. Kofteridis |
| author_sort | Petros Ioannou |
| collection | DOAJ |
| description | Despite recent medical research and clinical practice developments, the development of antimicrobial resistance (AMR) significantly limits therapeutics for infectious diseases. Thus, novel treatments for infectious diseases, especially in this era of increasing AMR, are urgently needed. There is ongoing research on non-classical therapies for infectious diseases utilizing alternative antimicrobial mechanisms to fight pathogens, such as bacteriophages or antimicrobial peptides (AMPs). AMPs are evolutionarily conserved molecules naturally produced by several organisms, such as plants, insects, marine organisms, and mammals, aiming to protect the host by fighting pathogenic microorganisms. There is ongoing research regarding developing AMPs for clinical use in infectious diseases. Moreover, AMPs have several other non-medical applications in the food industry, such as preservatives, animal husbandry, plant protection, and aquaculture. This review focuses on AMPs, their origins, biology, structure, mechanisms of action, non-medical applications, and clinical applications in infectious diseases. |
| first_indexed | 2024-03-10T23:47:12Z |
| format | Article |
| id | doaj.art-1bff798d01c14eddb2fb0e2c96b3acec |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T23:47:12Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-1bff798d01c14eddb2fb0e2c96b3acec2023-11-19T01:53:35ZengMDPI AGLife2075-17292023-07-01138165110.3390/life13081651Antimicrobial Peptides in Infectious Diseases and Beyond—A Narrative ReviewPetros Ioannou0Stella Baliou1Diamantis P. Kofteridis2School of Medicine, University of Crete, 71003 Heraklion, GreeceInternal Medicine, University Hospital of Heraklion, 71110 Heraklion, GreeceSchool of Medicine, University of Crete, 71003 Heraklion, GreeceDespite recent medical research and clinical practice developments, the development of antimicrobial resistance (AMR) significantly limits therapeutics for infectious diseases. Thus, novel treatments for infectious diseases, especially in this era of increasing AMR, are urgently needed. There is ongoing research on non-classical therapies for infectious diseases utilizing alternative antimicrobial mechanisms to fight pathogens, such as bacteriophages or antimicrobial peptides (AMPs). AMPs are evolutionarily conserved molecules naturally produced by several organisms, such as plants, insects, marine organisms, and mammals, aiming to protect the host by fighting pathogenic microorganisms. There is ongoing research regarding developing AMPs for clinical use in infectious diseases. Moreover, AMPs have several other non-medical applications in the food industry, such as preservatives, animal husbandry, plant protection, and aquaculture. This review focuses on AMPs, their origins, biology, structure, mechanisms of action, non-medical applications, and clinical applications in infectious diseases.https://www.mdpi.com/2075-1729/13/8/1651antimicrobial peptidesinfectious diseasesmicrobiologyantimicrobial resistanceantibiotics |
| spellingShingle | Petros Ioannou Stella Baliou Diamantis P. Kofteridis Antimicrobial Peptides in Infectious Diseases and Beyond—A Narrative Review Life antimicrobial peptides infectious diseases microbiology antimicrobial resistance antibiotics |
| title | Antimicrobial Peptides in Infectious Diseases and Beyond—A Narrative Review |
| title_full | Antimicrobial Peptides in Infectious Diseases and Beyond—A Narrative Review |
| title_fullStr | Antimicrobial Peptides in Infectious Diseases and Beyond—A Narrative Review |
| title_full_unstemmed | Antimicrobial Peptides in Infectious Diseases and Beyond—A Narrative Review |
| title_short | Antimicrobial Peptides in Infectious Diseases and Beyond—A Narrative Review |
| title_sort | antimicrobial peptides in infectious diseases and beyond a narrative review |
| topic | antimicrobial peptides infectious diseases microbiology antimicrobial resistance antibiotics |
| url | https://www.mdpi.com/2075-1729/13/8/1651 |
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