Targeted Therapy-Resistant Melanoma Cells Acquire Transcriptomic Similarities with Human Melanoblasts

Targeted Therapy-Resistant Melanoma Cells Acquire Transcriptomic Similarities with Human Melanoblasts

The mechanisms of adaptive and acquired drug resistance in tumors are not completely understood. So far, gene amplifications or mutations, leading to the reactivation of the MAPK or PI3K pathways have been described. In this study, we used two different methods to generate human melanoblasts: (1) vi...

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Bibliographic Details
Main Authors: Lionel Larribère, Silke Kuphal, Christos Sachpekidis, Sachindra, Laura Hüser, Anja Bosserhoff, Jochen Utikal
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cancers
Subjects:
melanoblast
melanoma
iPSCs
differentiation
resistance
Online Access:https://www.mdpi.com/2072-6694/10/11/451

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