Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis
Abstract Background In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (HRQoL), work productivity, and radiographic damage throughout the first...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-019-1811-4 |
| _version_ | 1811218055951286272 |
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| author | Kim Wervers Jolanda J. Luime Ilja Tchetverikov Andreas H. Gerards Marc R. Kok Cathelijne W. Y. Appels Wiebo L. van der Graaff Johannes H. L. M. van Groenendael Lindy-Anne Korswagen Josien J. Veris-van Dieren Johanna M. W. Hazes Marijn Vis on behalf of Cicero |
| author_facet | Kim Wervers Jolanda J. Luime Ilja Tchetverikov Andreas H. Gerards Marc R. Kok Cathelijne W. Y. Appels Wiebo L. van der Graaff Johannes H. L. M. van Groenendael Lindy-Anne Korswagen Josien J. Veris-van Dieren Johanna M. W. Hazes Marijn Vis on behalf of Cicero |
| author_sort | Kim Wervers |
| collection | DOAJ |
| description | Abstract Background In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (HRQoL), work productivity, and radiographic damage throughout the first year after diagnosis. Methods Data collected in the Dutch southwest early PsA cohort (DEPAR) study were analyzed. These three-monthly data encompassed disease activity, HRQOL was measured with the Short Form 36 (SF36) Physical Component Scale (SF36-PCS) and Mental Component Scale, and productivity was measured with the Productivity Cost Questionnaire. Radiographic damage was scored at baseline and at 12 months with the PsA-modified Sharp/van der Heijde score. Patients were classified by time to MDA as in early (within 3 months), late (at 6–12 months), and never MDA in the first year. Results We included 296 patients who had had their 1-year outpatient visit (mean age 51 years, 53% male). Ninety-six (32%) were classified as early MDA, 78 (26%) as late MDA, and 98 (33%) as never MDA. Data of 24 patients (8%) were missing. SF36-PCS and productivity scores improved after gaining MDA, but remained low in never MDA patients. At 1 year, SF36-PCS and productivity scores were similar in early and late MDA patients. Radiographic progression rate was low and similar in all groups. Conclusion Gaining MDA was associated with considerable improvement in HRQoL and functioning, irrespective of time to first MDA. In the one third of patients not in MDA in the first year, the disease had a substantial health impact. |
| first_indexed | 2024-04-12T07:03:16Z |
| format | Article |
| id | doaj.art-1c005614541e429da7b5518378e1046b |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-04-12T07:03:16Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-1c005614541e429da7b5518378e1046b2022-12-22T03:42:54ZengBMCArthritis Research & Therapy1478-63622019-01-012111710.1186/s13075-019-1811-4Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritisKim Wervers0Jolanda J. Luime1Ilja Tchetverikov2Andreas H. Gerards3Marc R. Kok4Cathelijne W. Y. Appels5Wiebo L. van der Graaff6Johannes H. L. M. van Groenendael7Lindy-Anne Korswagen8Josien J. Veris-van Dieren9Johanna M. W. Hazes10Marijn Vis11on behalf of CiceroDepartment of Rheumatology, Erasmus University Medical CenterDepartment of Rheumatology, Erasmus University Medical CenterDepartment of Rheumatology, Albert Schweitzer HospitalDepartment of Rheumatology, Vlietland HospitalDepartment of Rheumatology, Maasstad HospitalDepartment of Rheumatology, Amphia HospitalDepartment of Rheumatology, Rivas HospitalDepartment of Rheumatology, Reumazorg Zuid West NederlandDepartment of Rheumatology, Sint Franciscus GasthuisDepartment of Rheumatology, Reumazorg Zuid West NederlandDepartment of Rheumatology, Erasmus University Medical CenterDepartment of Rheumatology, Erasmus University Medical CenterAbstract Background In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (HRQoL), work productivity, and radiographic damage throughout the first year after diagnosis. Methods Data collected in the Dutch southwest early PsA cohort (DEPAR) study were analyzed. These three-monthly data encompassed disease activity, HRQOL was measured with the Short Form 36 (SF36) Physical Component Scale (SF36-PCS) and Mental Component Scale, and productivity was measured with the Productivity Cost Questionnaire. Radiographic damage was scored at baseline and at 12 months with the PsA-modified Sharp/van der Heijde score. Patients were classified by time to MDA as in early (within 3 months), late (at 6–12 months), and never MDA in the first year. Results We included 296 patients who had had their 1-year outpatient visit (mean age 51 years, 53% male). Ninety-six (32%) were classified as early MDA, 78 (26%) as late MDA, and 98 (33%) as never MDA. Data of 24 patients (8%) were missing. SF36-PCS and productivity scores improved after gaining MDA, but remained low in never MDA patients. At 1 year, SF36-PCS and productivity scores were similar in early and late MDA patients. Radiographic progression rate was low and similar in all groups. Conclusion Gaining MDA was associated with considerable improvement in HRQoL and functioning, irrespective of time to first MDA. In the one third of patients not in MDA in the first year, the disease had a substantial health impact.http://link.springer.com/article/10.1186/s13075-019-1811-4Psoriatic arthritisMinimal disease activityHealth-related quality of lifeProductivityComposite measure |
| spellingShingle | Kim Wervers Jolanda J. Luime Ilja Tchetverikov Andreas H. Gerards Marc R. Kok Cathelijne W. Y. Appels Wiebo L. van der Graaff Johannes H. L. M. van Groenendael Lindy-Anne Korswagen Josien J. Veris-van Dieren Johanna M. W. Hazes Marijn Vis on behalf of Cicero Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis Arthritis Research & Therapy Psoriatic arthritis Minimal disease activity Health-related quality of life Productivity Composite measure |
| title | Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
| title_full | Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
| title_fullStr | Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
| title_full_unstemmed | Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
| title_short | Time to minimal disease activity in relation to quality of life, productivity, and radiographic damage 1 year after diagnosis in psoriatic arthritis |
| title_sort | time to minimal disease activity in relation to quality of life productivity and radiographic damage 1 year after diagnosis in psoriatic arthritis |
| topic | Psoriatic arthritis Minimal disease activity Health-related quality of life Productivity Composite measure |
| url | http://link.springer.com/article/10.1186/s13075-019-1811-4 |
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