Actives from MMV Open Access Boxes? A suggested way forward.
It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billions of dollars every year. Collaborative drug disc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-04-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1009384 |
| _version_ | 1819141348616306688 |
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| author | Kirandeep Samby Paul A Willis Jeremy N Burrows Benoît Laleu Peter J H Webborn |
| author_facet | Kirandeep Samby Paul A Willis Jeremy N Burrows Benoît Laleu Peter J H Webborn |
| author_sort | Kirandeep Samby |
| collection | DOAJ |
| description | It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billions of dollars every year. Collaborative drug discovery efforts are required to reduce the burden of these diseases in endemic regions. The release of "Open Access Boxes" is an initiative launched by Medicines for Malaria Venture (MMV) in collaboration with its partners to catalyze new drug discovery in neglected diseases. These boxes are mainly requested by biology researchers across the globe who may not otherwise have access to compounds to screen nor knowledge of the workflow that needs to be followed after identification of actives from their screening campaigns. Here, we present guidelines on how to move such actives beyond the hit identification stage, to help in capacity strengthening and enable a greater impact of the initiative. |
| first_indexed | 2024-12-22T11:53:02Z |
| format | Article |
| id | doaj.art-1c007e1d50c645f39fc22e11900307c2 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-22T11:53:02Z |
| publishDate | 2021-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-1c007e1d50c645f39fc22e11900307c22022-12-21T18:26:55ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742021-04-01174e100938410.1371/journal.ppat.1009384Actives from MMV Open Access Boxes? A suggested way forward.Kirandeep SambyPaul A WillisJeremy N BurrowsBenoît LaleuPeter J H WebbornIt is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billions of dollars every year. Collaborative drug discovery efforts are required to reduce the burden of these diseases in endemic regions. The release of "Open Access Boxes" is an initiative launched by Medicines for Malaria Venture (MMV) in collaboration with its partners to catalyze new drug discovery in neglected diseases. These boxes are mainly requested by biology researchers across the globe who may not otherwise have access to compounds to screen nor knowledge of the workflow that needs to be followed after identification of actives from their screening campaigns. Here, we present guidelines on how to move such actives beyond the hit identification stage, to help in capacity strengthening and enable a greater impact of the initiative.https://doi.org/10.1371/journal.ppat.1009384 |
| spellingShingle | Kirandeep Samby Paul A Willis Jeremy N Burrows Benoît Laleu Peter J H Webborn Actives from MMV Open Access Boxes? A suggested way forward. PLoS Pathogens |
| title | Actives from MMV Open Access Boxes? A suggested way forward. |
| title_full | Actives from MMV Open Access Boxes? A suggested way forward. |
| title_fullStr | Actives from MMV Open Access Boxes? A suggested way forward. |
| title_full_unstemmed | Actives from MMV Open Access Boxes? A suggested way forward. |
| title_short | Actives from MMV Open Access Boxes? A suggested way forward. |
| title_sort | actives from mmv open access boxes a suggested way forward |
| url | https://doi.org/10.1371/journal.ppat.1009384 |
| work_keys_str_mv | AT kirandeepsamby activesfrommmvopenaccessboxesasuggestedwayforward AT paulawillis activesfrommmvopenaccessboxesasuggestedwayforward AT jeremynburrows activesfrommmvopenaccessboxesasuggestedwayforward AT benoitlaleu activesfrommmvopenaccessboxesasuggestedwayforward AT peterjhwebborn activesfrommmvopenaccessboxesasuggestedwayforward |