Current Aspects in the Biology, Pathogeny, and Treatment of Candida krusei, a Neglected Fungal Pathogen
Manuela Gómez-Gaviria, Héctor M Mora-Montes Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Guanajuato, Gto, MéxicoCorrespondence: Héctor M Mora-MontesDepartamento de B...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-06-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/current-aspects-in-the-biology-pathogeny-and-treatment-of-candida-krus-peer-reviewed-article-IDR |
| _version_ | 1828523604883537920 |
|---|---|
| author | Gómez-Gaviria M Mora-Montes HM |
| author_facet | Gómez-Gaviria M Mora-Montes HM |
| author_sort | Gómez-Gaviria M |
| collection | DOAJ |
| description | Manuela Gómez-Gaviria, Héctor M Mora-Montes Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Guanajuato, Gto, MéxicoCorrespondence: Héctor M Mora-MontesDepartamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, Col. Noria Alta, C.P. 36050, Guanajuato, Gto, MéxicoTel +52 473-7320006 Ext. 8193Fax +52 473-7320006 Ext. 8153Email hmora@ugto.mxAbstract: Fungal infections represent a constant and growing menace to human health, because of the emergence of new species as causative agents of diseases and the increment of antifungal drug resistance. Candidiasis is one of the most common fungal infections in humans and is associated with a high mortality rate when the fungi infect deep-seated organs. Candida krusei belongs to the group of candidiasis etiological agents, and although it is not isolated as frequently as other Candida species, the infections caused by this organism are of special relevance in the clinical setting because of its intrinsic resistance to fluconazole. Here, we offer a thorough revision of the current literature dealing with this organism and the caused disease, focusing on its biological aspects, the host-fungus interaction, the diagnosis, and the infection treatment. Of particular relevance, we provide the most recent genomic information, including the gene prediction of some putative virulence factors, like proteases, adhesins, regulators of biofilm formation and dimorphism. Moreover, C. krusei veterinary aspects and the exploration of natural products with anti-C. krusei activity are also included.Keywords: virulence, candidiasis, host-fungus interplay, antifungal drug, immune sensing |
| first_indexed | 2024-12-11T20:31:16Z |
| format | Article |
| id | doaj.art-1c05f6f762d6428a8f65c4af094beff2 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-11T20:31:16Z |
| publishDate | 2020-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-1c05f6f762d6428a8f65c4af094beff22022-12-22T00:51:48ZengDove Medical PressInfection and Drug Resistance1178-69732020-06-01Volume 131673168954415Current Aspects in the Biology, Pathogeny, and Treatment of Candida krusei, a Neglected Fungal PathogenGómez-Gaviria MMora-Montes HMManuela Gómez-Gaviria, Héctor M Mora-Montes Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Guanajuato, Gto, MéxicoCorrespondence: Héctor M Mora-MontesDepartamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, Col. Noria Alta, C.P. 36050, Guanajuato, Gto, MéxicoTel +52 473-7320006 Ext. 8193Fax +52 473-7320006 Ext. 8153Email hmora@ugto.mxAbstract: Fungal infections represent a constant and growing menace to human health, because of the emergence of new species as causative agents of diseases and the increment of antifungal drug resistance. Candidiasis is one of the most common fungal infections in humans and is associated with a high mortality rate when the fungi infect deep-seated organs. Candida krusei belongs to the group of candidiasis etiological agents, and although it is not isolated as frequently as other Candida species, the infections caused by this organism are of special relevance in the clinical setting because of its intrinsic resistance to fluconazole. Here, we offer a thorough revision of the current literature dealing with this organism and the caused disease, focusing on its biological aspects, the host-fungus interaction, the diagnosis, and the infection treatment. Of particular relevance, we provide the most recent genomic information, including the gene prediction of some putative virulence factors, like proteases, adhesins, regulators of biofilm formation and dimorphism. Moreover, C. krusei veterinary aspects and the exploration of natural products with anti-C. krusei activity are also included.Keywords: virulence, candidiasis, host-fungus interplay, antifungal drug, immune sensinghttps://www.dovepress.com/current-aspects-in-the-biology-pathogeny-and-treatment-of-candida-krus-peer-reviewed-article-IDRvirulencecandidiasishost-fungus interplayantifungal drugimmune sensing |
| spellingShingle | Gómez-Gaviria M Mora-Montes HM Current Aspects in the Biology, Pathogeny, and Treatment of Candida krusei, a Neglected Fungal Pathogen Infection and Drug Resistance virulence candidiasis host-fungus interplay antifungal drug immune sensing |
| title | Current Aspects in the Biology, Pathogeny, and Treatment of Candida krusei, a Neglected Fungal Pathogen |
| title_full | Current Aspects in the Biology, Pathogeny, and Treatment of Candida krusei, a Neglected Fungal Pathogen |
| title_fullStr | Current Aspects in the Biology, Pathogeny, and Treatment of Candida krusei, a Neglected Fungal Pathogen |
| title_full_unstemmed | Current Aspects in the Biology, Pathogeny, and Treatment of Candida krusei, a Neglected Fungal Pathogen |
| title_short | Current Aspects in the Biology, Pathogeny, and Treatment of Candida krusei, a Neglected Fungal Pathogen |
| title_sort | current aspects in the biology pathogeny and treatment of candida krusei a neglected fungal pathogen |
| topic | virulence candidiasis host-fungus interplay antifungal drug immune sensing |
| url | https://www.dovepress.com/current-aspects-in-the-biology-pathogeny-and-treatment-of-candida-krus-peer-reviewed-article-IDR |
| work_keys_str_mv | AT gomezgaviriam currentaspectsinthebiologypathogenyandtreatmentofcandidakruseianeglectedfungalpathogen AT moramonteshm currentaspectsinthebiologypathogenyandtreatmentofcandidakruseianeglectedfungalpathogen |