Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma
Cholangiocarcinoma (CCA) is an invasive cancer accounting for <1% of all cancers and 10–15% of primary liver cancers. Intrahepatic CCA (iCCA) is associated with poor survival rates and high post-surgical recurrence rates whilst most diagnosed patients are not surgical candidates. There is a growi...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/7/1186 |
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| author | Georgios Charalampopoulos Roberto Iezzi Maria Tsitskari Argyro Mazioti Olympia Papakonstantinou Alexis Kelekis Nikolaos Kelekis Dimitrios Filippiadis |
| author_facet | Georgios Charalampopoulos Roberto Iezzi Maria Tsitskari Argyro Mazioti Olympia Papakonstantinou Alexis Kelekis Nikolaos Kelekis Dimitrios Filippiadis |
| author_sort | Georgios Charalampopoulos |
| collection | DOAJ |
| description | Cholangiocarcinoma (CCA) is an invasive cancer accounting for <1% of all cancers and 10–15% of primary liver cancers. Intrahepatic CCA (iCCA) is associated with poor survival rates and high post-surgical recurrence rates whilst most diagnosed patients are not surgical candidates. There is a growing literature suggesting percutaneous ablative techniques for the management of patients with iCCA measuring ≤3 cm with contraindications to surgery as well as for recurrent or residual tumors aiming to provide local cancer treatment and control. Most used ablative therapies for iCCA include radiofrequency and microwave ablation with irreversible electroporation, cryoablation and reversible electroporation (electrochemotherapy) being less commonly encountered techniques. Due to the infiltrative margins of the lesion, there is a need for larger safety margins and ablation zone; multi-apparatus ablation or other variations of the technique such as balloon-assisted approaches can be utilized aiming to increase size of the zone of necrosis. The present review paper focuses upon the current role of percutaneous ablative techniques for the therapeutic management of iCCA. The purpose of this review is to present the current minimally invasive ablative techniques in the treatment of iCCA, including local control and survival rates. |
| first_indexed | 2024-03-11T00:51:29Z |
| format | Article |
| id | doaj.art-1c062e36acbc4819a7d7d02d57ff0959 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T00:51:29Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-1c062e36acbc4819a7d7d02d57ff09592023-11-18T20:23:00ZengMDPI AGMedicina1010-660X1648-91442023-06-01597118610.3390/medicina59071186Role of Percutaneous Ablation in the Management of Intrahepatic CholangiocarcinomaGeorgios Charalampopoulos0Roberto Iezzi1Maria Tsitskari2Argyro Mazioti3Olympia Papakonstantinou4Alexis Kelekis5Nikolaos Kelekis6Dimitrios Filippiadis72nd Department of Radiology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Diagnostic Imaging, Oncologic Radiotherapy and Hematology, A. Gemelli University Hospital Foundation IRCCS, Catholic University of the Sacred Heart, 00168 Rome, ItalyApollonio Private Hospital, 20 Lefkotheou Avenue, 2054 Strovolos, Nicosia, Cyprus2nd Department of Radiology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Radiology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Radiology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Radiology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Radiology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceCholangiocarcinoma (CCA) is an invasive cancer accounting for <1% of all cancers and 10–15% of primary liver cancers. Intrahepatic CCA (iCCA) is associated with poor survival rates and high post-surgical recurrence rates whilst most diagnosed patients are not surgical candidates. There is a growing literature suggesting percutaneous ablative techniques for the management of patients with iCCA measuring ≤3 cm with contraindications to surgery as well as for recurrent or residual tumors aiming to provide local cancer treatment and control. Most used ablative therapies for iCCA include radiofrequency and microwave ablation with irreversible electroporation, cryoablation and reversible electroporation (electrochemotherapy) being less commonly encountered techniques. Due to the infiltrative margins of the lesion, there is a need for larger safety margins and ablation zone; multi-apparatus ablation or other variations of the technique such as balloon-assisted approaches can be utilized aiming to increase size of the zone of necrosis. The present review paper focuses upon the current role of percutaneous ablative techniques for the therapeutic management of iCCA. The purpose of this review is to present the current minimally invasive ablative techniques in the treatment of iCCA, including local control and survival rates.https://www.mdpi.com/1648-9144/59/7/1186intrahepatic cholangiocarcinomaablationcancer |
| spellingShingle | Georgios Charalampopoulos Roberto Iezzi Maria Tsitskari Argyro Mazioti Olympia Papakonstantinou Alexis Kelekis Nikolaos Kelekis Dimitrios Filippiadis Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma Medicina intrahepatic cholangiocarcinoma ablation cancer |
| title | Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma |
| title_full | Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma |
| title_fullStr | Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma |
| title_full_unstemmed | Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma |
| title_short | Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma |
| title_sort | role of percutaneous ablation in the management of intrahepatic cholangiocarcinoma |
| topic | intrahepatic cholangiocarcinoma ablation cancer |
| url | https://www.mdpi.com/1648-9144/59/7/1186 |
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