Effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia: a randomized controlled trial
IntroductionObesity and iron deficiency are prevalent health problems that affect billions of people all over the world. Obesity is postulated to relate to iron deficiency via reduced intestinal iron absorption due to increased serum hepcidin level, which is mediated by chronic inflammation. Weight...
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1155947/full |
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| author | Naseem Mohammad Alshwaiyat Aryati Ahmad Hamid Ali Nagi Al-Jamal |
| author_facet | Naseem Mohammad Alshwaiyat Aryati Ahmad Hamid Ali Nagi Al-Jamal |
| author_sort | Naseem Mohammad Alshwaiyat |
| collection | DOAJ |
| description | IntroductionObesity and iron deficiency are prevalent health problems that affect billions of people all over the world. Obesity is postulated to relate to iron deficiency via reduced intestinal iron absorption due to increased serum hepcidin level, which is mediated by chronic inflammation. Weight loss in individuals with overweight or obesity and iron deficiency anemia is believed to be associated with an improvement in iron status however the evidence from clinical trials is scarce. This study was conducted to evaluate the effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia.MethodsThe study design was a single-blinded, randomized controlled trial with two parallel arms (weight loss intervention vs control). Study participants were recruited using the convenience sampling method through public advertisements posted and disseminated through social media. Interested and potential participants were asked to visit the Diet Clinic for eligibility screening. A total of 62 women were recruited and randomized into weight loss intervention and control group. The intervention duration was three months. The intervention group received individual consultation sessions with the dietitian and tailored energy-restricted diets. Physical activity levels, dietary intake, anthropometric measurements and clinical markers were measured at baseline and end of the trial.ResultsThere was a significant decrease (p < 0.001) in body weight of the intervention group (-7.4 ± 2.7 kg) that was associated with significant improvements in iron status and its markers (p < 0.01). The intervention group experienced a significant increase in hemoglobin (0.5 ± 0.6 g/dL), serum ferritin (5.6 ± 5.8 ng/mL), and serum iron (13.0 ± 16.2 µg/dL), and a significant decrease in high-sensitivity C-reactive protein (-5.2 ± 5.6 mg/L), and serum hepcidin level (-1.9 ± 2.2 ng/mL) at the end of the trial.ConclusionOur findings indicate that diet-induced weight loss among participants was associated with an improvement in iron status and its related clinical markers.Clinical Trial Registration[https://www.thaiclinicaltrials.org/show/TCTR20221009001], identifier [TCTR20221009001]. |
| first_indexed | 2024-03-13T10:09:14Z |
| format | Article |
| id | doaj.art-1c0975a3434c4a6ca6192111feef5be6 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T10:09:14Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj.art-1c0975a3434c4a6ca6192111feef5be62023-05-22T04:54:54ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-05-011010.3389/fnut.2023.11559471155947Effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia: a randomized controlled trialNaseem Mohammad Alshwaiyat0Aryati Ahmad1Hamid Ali Nagi Al-Jamal2School of Nutrition and Dietetics, Faculty of Health Sciences, Gong Badak Campus, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu, MalaysiaSchool of Nutrition and Dietetics, Faculty of Health Sciences, Gong Badak Campus, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu, MalaysiaSchool of Biomedicine, Faculty of Health Sciences, Gong Badak Campus, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu, MalaysiaIntroductionObesity and iron deficiency are prevalent health problems that affect billions of people all over the world. Obesity is postulated to relate to iron deficiency via reduced intestinal iron absorption due to increased serum hepcidin level, which is mediated by chronic inflammation. Weight loss in individuals with overweight or obesity and iron deficiency anemia is believed to be associated with an improvement in iron status however the evidence from clinical trials is scarce. This study was conducted to evaluate the effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia.MethodsThe study design was a single-blinded, randomized controlled trial with two parallel arms (weight loss intervention vs control). Study participants were recruited using the convenience sampling method through public advertisements posted and disseminated through social media. Interested and potential participants were asked to visit the Diet Clinic for eligibility screening. A total of 62 women were recruited and randomized into weight loss intervention and control group. The intervention duration was three months. The intervention group received individual consultation sessions with the dietitian and tailored energy-restricted diets. Physical activity levels, dietary intake, anthropometric measurements and clinical markers were measured at baseline and end of the trial.ResultsThere was a significant decrease (p < 0.001) in body weight of the intervention group (-7.4 ± 2.7 kg) that was associated with significant improvements in iron status and its markers (p < 0.01). The intervention group experienced a significant increase in hemoglobin (0.5 ± 0.6 g/dL), serum ferritin (5.6 ± 5.8 ng/mL), and serum iron (13.0 ± 16.2 µg/dL), and a significant decrease in high-sensitivity C-reactive protein (-5.2 ± 5.6 mg/L), and serum hepcidin level (-1.9 ± 2.2 ng/mL) at the end of the trial.ConclusionOur findings indicate that diet-induced weight loss among participants was associated with an improvement in iron status and its related clinical markers.Clinical Trial Registration[https://www.thaiclinicaltrials.org/show/TCTR20221009001], identifier [TCTR20221009001].https://www.frontiersin.org/articles/10.3389/fnut.2023.1155947/fullweight lossobesityiron statuschronic inflammationhepcidiniron deficiency anemia |
| spellingShingle | Naseem Mohammad Alshwaiyat Aryati Ahmad Hamid Ali Nagi Al-Jamal Effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia: a randomized controlled trial Frontiers in Nutrition weight loss obesity iron status chronic inflammation hepcidin iron deficiency anemia |
| title | Effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia: a randomized controlled trial |
| title_full | Effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia: a randomized controlled trial |
| title_fullStr | Effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia: a randomized controlled trial |
| title_full_unstemmed | Effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia: a randomized controlled trial |
| title_short | Effect of diet-induced weight loss on iron status and its markers among young women with overweight/obesity and iron deficiency anemia: a randomized controlled trial |
| title_sort | effect of diet induced weight loss on iron status and its markers among young women with overweight obesity and iron deficiency anemia a randomized controlled trial |
| topic | weight loss obesity iron status chronic inflammation hepcidin iron deficiency anemia |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1155947/full |
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