Pathogenesis of Acquired Aplastic Anemia and the Role of the Bone Marrow Microenvironment

Pathogenesis of Acquired Aplastic Anemia and the Role of the Bone Marrow Microenvironment

Aplastic anemia (AA) is characterized by bone marrow (BM) hypocellularity, resulting in peripheral cytopenias. An antigen-driven and likely auto-immune dysregulated T-cell homeostasis results in hematopoietic stem cell injury, which ultimately leads to the pathogenesis of the acquired form of this d...

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Bibliographic Details
Main Authors: Michael Medinger, Beatrice Drexler, Claudia Lengerke, Jakob Passweg
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Oncology
Subjects:
aplastic anemia
microenvironment
microvessel density
mesenchymal stem cells
stem cell niche
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00587/full

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