Expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes

Expansion of human alpha‐cell area is associated with a higher maximum body mass index before the onset of type 2 diabetes

Highlights We examined whether maximum body mass index (BMI) before the onset of diabetes (MBBO) affects histological findings of islet cells. We divided patients into two groups according to an MBBO cutoff of 25 kg/m2 or BMI cutoff of 21 kg/m2. We compared immunohistochemical parameters between the...

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Bibliographic Details
Main Authors: Harutoshi Ozawa, Kenji Fukui, Yukari Fujita, Chisaki Ishibashi, Sho Yoneda, Takao Nammo, Shingo Fujita, Megu Yamaguchi Baden, Takekazu Kimura, Ayumi Tokunaga, Junji Kozawa, Hidetoshi Eguchi, Iichiro Shimomura
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Journal of Diabetes
Online Access:https://doi.org/10.1111/1753-0407.13370
Description
Summary:Highlights We examined whether maximum body mass index (BMI) before the onset of diabetes (MBBO) affects histological findings of islet cells. We divided patients into two groups according to an MBBO cutoff of 25 kg/m2 or BMI cutoff of 21 kg/m2. We compared immunohistochemical parameters between the MBBO groups or BMI groups. The relative alpha‐cell area in the high MBBO group was significantly higher than that in the low MBBO group. There was no difference in the other parameters between the MBBO groups or BMI groups.
ISSN:1753-0393
1753-0407

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