Endophytic Fungi as a Source of Antibacterial Compounds—A Focus on Gram-Negative Bacteria
Bacterial resistance has become one of the main motives in the worldwide race for undescribed antibacterial agents. The difficulties in the treatment of bacterial infections are a public health issue that increasingly highlights the need for antimicrobial agents. Endophytic microorganisms are a prom...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/11/11/1509 |
| _version_ | 1797469324012683264 |
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| author | Dayse Pereira Dias Silva Macley Silva Cardoso Alexandre José Macedo |
| author_facet | Dayse Pereira Dias Silva Macley Silva Cardoso Alexandre José Macedo |
| author_sort | Dayse Pereira Dias Silva |
| collection | DOAJ |
| description | Bacterial resistance has become one of the main motives in the worldwide race for undescribed antibacterial agents. The difficulties in the treatment of bacterial infections are a public health issue that increasingly highlights the need for antimicrobial agents. Endophytic microorganisms are a promising alternative in the search for drugs, due to the vast number of metabolites produced with unique characteristics and bioactive potential. This review highlights the importance of endophytic microorganisms as a source of secondary metabolites in the search for active molecules against bacteria of medical importance, with a special focus on gram-negative species. This fact is supported by the findings raised in this review, which brings an arsenal of 166 molecules with characterized chemical structures and their antibacterial activities. In addition, the low cost, ease of maintenance, and optimization-controlled fermentation conditions favor reproducibility in commercial scale. Given their importance, it is necessary to intensify the search for new molecules from endophytic microorganisms, and to increasingly invest in this very promising font. |
| first_indexed | 2024-03-09T19:19:46Z |
| format | Article |
| id | doaj.art-1c0e8367c62541deb311875e630a9976 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T19:19:46Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-1c0e8367c62541deb311875e630a99762023-11-24T03:27:32ZengMDPI AGAntibiotics2079-63822022-10-011111150910.3390/antibiotics11111509Endophytic Fungi as a Source of Antibacterial Compounds—A Focus on Gram-Negative BacteriaDayse Pereira Dias Silva0Macley Silva Cardoso1Alexandre José Macedo2Laboratório de Diversidade Microbiana (LabDiM), Centro de Biotecnologia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, Porto Alegre 91501-970, BrazilLaboratório de Diversidade Microbiana (LabDiM), Centro de Biotecnologia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, Porto Alegre 91501-970, BrazilLaboratório de Diversidade Microbiana (LabDiM), Centro de Biotecnologia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, Porto Alegre 91501-970, BrazilBacterial resistance has become one of the main motives in the worldwide race for undescribed antibacterial agents. The difficulties in the treatment of bacterial infections are a public health issue that increasingly highlights the need for antimicrobial agents. Endophytic microorganisms are a promising alternative in the search for drugs, due to the vast number of metabolites produced with unique characteristics and bioactive potential. This review highlights the importance of endophytic microorganisms as a source of secondary metabolites in the search for active molecules against bacteria of medical importance, with a special focus on gram-negative species. This fact is supported by the findings raised in this review, which brings an arsenal of 166 molecules with characterized chemical structures and their antibacterial activities. In addition, the low cost, ease of maintenance, and optimization-controlled fermentation conditions favor reproducibility in commercial scale. Given their importance, it is necessary to intensify the search for new molecules from endophytic microorganisms, and to increasingly invest in this very promising font.https://www.mdpi.com/2079-6382/11/11/1509antibacterial activityendophytic fungimetabolitesgram-negative bacteria |
| spellingShingle | Dayse Pereira Dias Silva Macley Silva Cardoso Alexandre José Macedo Endophytic Fungi as a Source of Antibacterial Compounds—A Focus on Gram-Negative Bacteria Antibiotics antibacterial activity endophytic fungi metabolites gram-negative bacteria |
| title | Endophytic Fungi as a Source of Antibacterial Compounds—A Focus on Gram-Negative Bacteria |
| title_full | Endophytic Fungi as a Source of Antibacterial Compounds—A Focus on Gram-Negative Bacteria |
| title_fullStr | Endophytic Fungi as a Source of Antibacterial Compounds—A Focus on Gram-Negative Bacteria |
| title_full_unstemmed | Endophytic Fungi as a Source of Antibacterial Compounds—A Focus on Gram-Negative Bacteria |
| title_short | Endophytic Fungi as a Source of Antibacterial Compounds—A Focus on Gram-Negative Bacteria |
| title_sort | endophytic fungi as a source of antibacterial compounds a focus on gram negative bacteria |
| topic | antibacterial activity endophytic fungi metabolites gram-negative bacteria |
| url | https://www.mdpi.com/2079-6382/11/11/1509 |
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