Antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of Bangladesh
Abstract Background Antimicrobial resistance is an emerging concern globally in recent years. Management of common infectious diseases like urinary tract infection (UTI) has become challenging. In this context, the purpose of this study is to compare the shifting trends in bacteriology and antibioti...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Antimicrobial Resistance and Infection Control |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13756-022-01197-6 |
| _version_ | 1811203819454857216 |
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| author | Md. Mahabubul Islam Majumder Ashrafur Rahaman Mahadi Tareq Ahmed Mostaque Ahmed Mohammad Nazim Uddin Md. Zahirul Alam |
| author_facet | Md. Mahabubul Islam Majumder Ashrafur Rahaman Mahadi Tareq Ahmed Mostaque Ahmed Mohammad Nazim Uddin Md. Zahirul Alam |
| author_sort | Md. Mahabubul Islam Majumder |
| collection | DOAJ |
| description | Abstract Background Antimicrobial resistance is an emerging concern globally in recent years. Management of common infectious diseases like urinary tract infection (UTI) has become challenging. In this context, the purpose of this study is to compare the shifting trends in bacteriology and antibiotic resistance pattern among uropathogens to similar studies conducted at various times in Bangladesh. Methods It was a cross-sectional study conducted at the CUMILLA MEDICAL COLLEGE HOSPITAL’S MEDICINE DEPARTMENT in three phases (2011, 2016, 2021. Patients who visited the outpatient and inpatient departments of the study center with symptoms suggestive of a urinary tract infection were undergone urine culture. Those who yielded positive growth in urne culture were finally included in the study. Results Escherichia coli (62% in 2021, 86% in 2016 and 76% in 2011) and Klebsiella species (11% in 2021, 10% in 2016 and 11% in 2011) were the most frequently isolated bacteria. Overall, in Gram-negative organisms, resistance was almost > 50% to all the tested antibiotics. Very high frequency of resistance ranging from 66.67 to 93.75% to cotrimoxazole, ciprofloxacin, cefuroxime, cephradine, amoxicillin and nalidixic acid, moderately high resistance to ceftriaxone (64.52%) and gentamicin (53.13%) and low resistance to nitrofurantoin (25.38%) were shown by the most commonly isolated organisms. Resistance to common antibiotics has been significantly increased over time in the isolated orgnaisms, especially in carbapenem and aminoglycoside group. Conclusion Resistance of uropathogens against conventional antibiotics used to treat UTI is high and the proportion has been increased over time. The situation might be grave in upcoming years if rational consumption of antibiotics is not warranted. |
| first_indexed | 2024-04-12T03:01:24Z |
| format | Article |
| id | doaj.art-1c11183d7da94ba193de30a5fa6d9ebf |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-04-12T03:01:24Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-1c11183d7da94ba193de30a5fa6d9ebf2022-12-22T03:50:38ZengBMCAntimicrobial Resistance and Infection Control2047-29942022-12-011111810.1186/s13756-022-01197-6Antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of BangladeshMd. Mahabubul Islam Majumder0Ashrafur Rahaman Mahadi1Tareq Ahmed2Mostaque Ahmed3Mohammad Nazim Uddin4Md. Zahirul Alam5Department of Medicine, Central Medical CollegeCentral Medical CollegeCumilla Medical CollegeDepartment of Medicine, Central Medical CollegeDepartment of Medicine, Central Medical CollegeDepartment of Pediatrics, Central Medical CollegeAbstract Background Antimicrobial resistance is an emerging concern globally in recent years. Management of common infectious diseases like urinary tract infection (UTI) has become challenging. In this context, the purpose of this study is to compare the shifting trends in bacteriology and antibiotic resistance pattern among uropathogens to similar studies conducted at various times in Bangladesh. Methods It was a cross-sectional study conducted at the CUMILLA MEDICAL COLLEGE HOSPITAL’S MEDICINE DEPARTMENT in three phases (2011, 2016, 2021. Patients who visited the outpatient and inpatient departments of the study center with symptoms suggestive of a urinary tract infection were undergone urine culture. Those who yielded positive growth in urne culture were finally included in the study. Results Escherichia coli (62% in 2021, 86% in 2016 and 76% in 2011) and Klebsiella species (11% in 2021, 10% in 2016 and 11% in 2011) were the most frequently isolated bacteria. Overall, in Gram-negative organisms, resistance was almost > 50% to all the tested antibiotics. Very high frequency of resistance ranging from 66.67 to 93.75% to cotrimoxazole, ciprofloxacin, cefuroxime, cephradine, amoxicillin and nalidixic acid, moderately high resistance to ceftriaxone (64.52%) and gentamicin (53.13%) and low resistance to nitrofurantoin (25.38%) were shown by the most commonly isolated organisms. Resistance to common antibiotics has been significantly increased over time in the isolated orgnaisms, especially in carbapenem and aminoglycoside group. Conclusion Resistance of uropathogens against conventional antibiotics used to treat UTI is high and the proportion has been increased over time. The situation might be grave in upcoming years if rational consumption of antibiotics is not warranted.https://doi.org/10.1186/s13756-022-01197-6UTIAntimicrobialsAntibiotics resistanceBangladeshHospitals |
| spellingShingle | Md. Mahabubul Islam Majumder Ashrafur Rahaman Mahadi Tareq Ahmed Mostaque Ahmed Mohammad Nazim Uddin Md. Zahirul Alam Antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of Bangladesh Antimicrobial Resistance and Infection Control UTI Antimicrobials Antibiotics resistance Bangladesh Hospitals |
| title | Antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of Bangladesh |
| title_full | Antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of Bangladesh |
| title_fullStr | Antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of Bangladesh |
| title_full_unstemmed | Antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of Bangladesh |
| title_short | Antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of Bangladesh |
| title_sort | antibiotic resistance pattern of microorganisms causing urinary tract infection a 10 year comparative analysis in a tertiary care hospital of bangladesh |
| topic | UTI Antimicrobials Antibiotics resistance Bangladesh Hospitals |
| url | https://doi.org/10.1186/s13756-022-01197-6 |
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