Diagnosis and Pharmacologic Management of Fibrotic Interstitial Lung Disease
Interstitial lung disease is an umbrella term that encompasses a spectrum of parenchymal lung pathologies affecting the gas exchanging part of the lung. While many of these disease entities are not fibrotic in nature, a number can lead to pulmonary fibrosis which may or may not progress over time. I...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/3/599 |
| _version_ | 1827749085898080256 |
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| author | Kristin Berger Robert J. Kaner |
| author_facet | Kristin Berger Robert J. Kaner |
| author_sort | Kristin Berger |
| collection | DOAJ |
| description | Interstitial lung disease is an umbrella term that encompasses a spectrum of parenchymal lung pathologies affecting the gas exchanging part of the lung. While many of these disease entities are not fibrotic in nature, a number can lead to pulmonary fibrosis which may or may not progress over time. Idiopathic pulmonary fibrosis is the prototypical, progressive fibrotic interstitial lung disease, which can lead to worsening hypoxemic respiratory failure and mortality within a number of years from the time of diagnosis. The importance of an accurate and timely diagnosis of interstitial lung diseases, which is needed to inform prognosis and guide clinical management, cannot be overemphasized. Developing a consensus diagnosis requires the incorporation of a variety of factors by a multidisciplinary team, which then may or may not determine a need for tissue sampling. Clinical management can be challenging given the heterogeneity of disease behavior and the paucity of controlled trials to guide decision making. This review addresses current paradigms and recent updates in the diagnosis and pharmacologic management of these fibrotic interstitial lung diseases. |
| first_indexed | 2024-03-11T06:16:56Z |
| format | Article |
| id | doaj.art-1c1137a89f414f96b38b96f7a47b1776 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T06:16:56Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-1c1137a89f414f96b38b96f7a47b17762023-11-17T12:09:45ZengMDPI AGLife2075-17292023-02-0113359910.3390/life13030599Diagnosis and Pharmacologic Management of Fibrotic Interstitial Lung DiseaseKristin Berger0Robert J. Kaner1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USADivision of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USAInterstitial lung disease is an umbrella term that encompasses a spectrum of parenchymal lung pathologies affecting the gas exchanging part of the lung. While many of these disease entities are not fibrotic in nature, a number can lead to pulmonary fibrosis which may or may not progress over time. Idiopathic pulmonary fibrosis is the prototypical, progressive fibrotic interstitial lung disease, which can lead to worsening hypoxemic respiratory failure and mortality within a number of years from the time of diagnosis. The importance of an accurate and timely diagnosis of interstitial lung diseases, which is needed to inform prognosis and guide clinical management, cannot be overemphasized. Developing a consensus diagnosis requires the incorporation of a variety of factors by a multidisciplinary team, which then may or may not determine a need for tissue sampling. Clinical management can be challenging given the heterogeneity of disease behavior and the paucity of controlled trials to guide decision making. This review addresses current paradigms and recent updates in the diagnosis and pharmacologic management of these fibrotic interstitial lung diseases.https://www.mdpi.com/2075-1729/13/3/599pulmonary fibrosisinterstitial lung diseasedrug therapydiagnostic techniquesprocedures |
| spellingShingle | Kristin Berger Robert J. Kaner Diagnosis and Pharmacologic Management of Fibrotic Interstitial Lung Disease Life pulmonary fibrosis interstitial lung disease drug therapy diagnostic techniques procedures |
| title | Diagnosis and Pharmacologic Management of Fibrotic Interstitial Lung Disease |
| title_full | Diagnosis and Pharmacologic Management of Fibrotic Interstitial Lung Disease |
| title_fullStr | Diagnosis and Pharmacologic Management of Fibrotic Interstitial Lung Disease |
| title_full_unstemmed | Diagnosis and Pharmacologic Management of Fibrotic Interstitial Lung Disease |
| title_short | Diagnosis and Pharmacologic Management of Fibrotic Interstitial Lung Disease |
| title_sort | diagnosis and pharmacologic management of fibrotic interstitial lung disease |
| topic | pulmonary fibrosis interstitial lung disease drug therapy diagnostic techniques procedures |
| url | https://www.mdpi.com/2075-1729/13/3/599 |
| work_keys_str_mv | AT kristinberger diagnosisandpharmacologicmanagementoffibroticinterstitiallungdisease AT robertjkaner diagnosisandpharmacologicmanagementoffibroticinterstitiallungdisease |