Novel Brain-Penetrant, Small-Molecule Tubulin Destabilizers for the Treatment of Glioblastoma

Novel Brain-Penetrant, Small-Molecule Tubulin Destabilizers for the Treatment of Glioblastoma

Glioblastoma (GB) is the most lethal brain cancer in adults, with a 5-year survival rate of 5%. The standard of care for GB includes maximally safe surgical resection, radiation, and temozolomide (TMZ) therapy, but tumor recurrence is inevitable in most GB patients. Here, we describe the development...

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Bibliographic Details
Main Authors: Lilian A. Patrón, Helen Yeoman, Sydney Wilson, Nanyun Tang, Michael E. Berens, Vijay Gokhale, Teri C. Suzuki
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biomedicines
Subjects:
glioblastoma
brain cancers
small molecules
microtubules
tubulin destabilizer
Online Access:https://www.mdpi.com/2227-9059/12/2/406

Internet

https://www.mdpi.com/2227-9059/12/2/406

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