Analgesic efficacy of diazepam and placebo in patients with temporomandibular disorders: A double blind randomized clinical trial
Aim: The aim of the study was to evaluate and compare the analgesic efficacy of placebo and diazepam in patients with temporomandibular disorder. Materials and Methods: Thirty-five patients were recruited with a diagnosis of temporomandibular disorder based on standard clinical diagnostic criteria...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2011;volume=22;issue=3;spage=404;epage=409;aulast=Pramod |
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| author | G V Pramod P Shambulingappa M C Shashikanth Shailesh Lele |
| author_facet | G V Pramod P Shambulingappa M C Shashikanth Shailesh Lele |
| author_sort | G V Pramod |
| collection | DOAJ |
| description | Aim: The aim of the study was to evaluate and compare the analgesic efficacy of placebo and diazepam in patients with temporomandibular disorder.
Materials and Methods: Thirty-five patients were recruited with a diagnosis of temporomandibular disorder based on standard clinical diagnostic criteria for temporomandibular disorder. The patients were put in to one of the two groups: placebo or diazepam at random. The average pain intensity was recorded with visual analog scale (VAS) at pretreatment, at weekly interval till the completion of a three-week trial and at post-treatment visit on the eighth week from baseline. The secondary outcome measures were changes in masticatory muscle tenderness, viz. massater muscle, lateral pterygoid muscle, medial pterygoid muscle and temporalis muscle and changes in mouth opening.
Statistical Analysis: Intra-group comparison for analgesic efficacy and mouth opening was carried out by Wilcoxon′s signed ranked test. Inter-group comparison for analgesic efficacy was also carried out using Mann-Whitney′s test.
Results: A statistically significant (P<0.01) decrease in temporomandibular disorder pain in the placebo group (65%) and statistically highly significant (P<0.001) decrease in the diazepam group (72%) were observed on VAS after three weeks of treatment. The inter-group comparison demonstrated no statistically significant difference between the groups.
Conclusion: This study suggests that the placebo can give near similar results as diazepam can. So the role of placebo should also be considered as one of the important management strategies. In the short term, reduction in the masticatory muscle tenderness and significant improvement in the mouth opening in both the groups were observed. |
| first_indexed | 2024-04-12T19:31:36Z |
| format | Article |
| id | doaj.art-1c13daae993b4bb483e0c8f4edd1b544 |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-04-12T19:31:36Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-1c13daae993b4bb483e0c8f4edd1b5442022-12-22T03:19:19ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032011-01-0122340440910.4103/0970-9290.87062Analgesic efficacy of diazepam and placebo in patients with temporomandibular disorders: A double blind randomized clinical trialG V PramodP ShambulingappaM C ShashikanthShailesh LeleAim: The aim of the study was to evaluate and compare the analgesic efficacy of placebo and diazepam in patients with temporomandibular disorder. Materials and Methods: Thirty-five patients were recruited with a diagnosis of temporomandibular disorder based on standard clinical diagnostic criteria for temporomandibular disorder. The patients were put in to one of the two groups: placebo or diazepam at random. The average pain intensity was recorded with visual analog scale (VAS) at pretreatment, at weekly interval till the completion of a three-week trial and at post-treatment visit on the eighth week from baseline. The secondary outcome measures were changes in masticatory muscle tenderness, viz. massater muscle, lateral pterygoid muscle, medial pterygoid muscle and temporalis muscle and changes in mouth opening. Statistical Analysis: Intra-group comparison for analgesic efficacy and mouth opening was carried out by Wilcoxon′s signed ranked test. Inter-group comparison for analgesic efficacy was also carried out using Mann-Whitney′s test. Results: A statistically significant (P<0.01) decrease in temporomandibular disorder pain in the placebo group (65%) and statistically highly significant (P<0.001) decrease in the diazepam group (72%) were observed on VAS after three weeks of treatment. The inter-group comparison demonstrated no statistically significant difference between the groups. Conclusion: This study suggests that the placebo can give near similar results as diazepam can. So the role of placebo should also be considered as one of the important management strategies. In the short term, reduction in the masticatory muscle tenderness and significant improvement in the mouth opening in both the groups were observed.http://www.ijdr.in/article.asp?issn=0970-9290;year=2011;volume=22;issue=3;spage=404;epage=409;aulast=PramodAnalgesic efficacydiazepamdouble-blind randomized clinical trialplacebotemporomandibular disorders |
| spellingShingle | G V Pramod P Shambulingappa M C Shashikanth Shailesh Lele Analgesic efficacy of diazepam and placebo in patients with temporomandibular disorders: A double blind randomized clinical trial Indian Journal of Dental Research Analgesic efficacy diazepam double-blind randomized clinical trial placebo temporomandibular disorders |
| title | Analgesic efficacy of diazepam and placebo in patients with temporomandibular disorders: A double blind randomized clinical trial |
| title_full | Analgesic efficacy of diazepam and placebo in patients with temporomandibular disorders: A double blind randomized clinical trial |
| title_fullStr | Analgesic efficacy of diazepam and placebo in patients with temporomandibular disorders: A double blind randomized clinical trial |
| title_full_unstemmed | Analgesic efficacy of diazepam and placebo in patients with temporomandibular disorders: A double blind randomized clinical trial |
| title_short | Analgesic efficacy of diazepam and placebo in patients with temporomandibular disorders: A double blind randomized clinical trial |
| title_sort | analgesic efficacy of diazepam and placebo in patients with temporomandibular disorders a double blind randomized clinical trial |
| topic | Analgesic efficacy diazepam double-blind randomized clinical trial placebo temporomandibular disorders |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2011;volume=22;issue=3;spage=404;epage=409;aulast=Pramod |
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