Prevalence and risk factors of acquired aplastic anemia among men aged 15 years and above referred for hematological consultation at Parirenyatwa Group of Hospital Zimbabwe 2020–2022: A case-control study
Introduction: Data on aplastic anemia (AA) is currently very scarce in Africa and Zimbabwe, despite rising cases of acquire aplastic anemia (AAA) observed among young men. We explore AAA risk factors, hematological parameters, patient prevalence, and control. Materials and Methods: This is a case-co...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | MGM Journal of Medical Sciences |
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| Online Access: | http://www.mgmjms.com/article.asp?issn=2347-7946;year=2023;volume=10;issue=2;spage=210;epage=217;aulast=Makaza |
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| author | Mutsa Makaza Abdoul Razak Mahaman Yacoubou Maibouge Tanko Mahamane Salissou |
| author_facet | Mutsa Makaza Abdoul Razak Mahaman Yacoubou Maibouge Tanko Mahamane Salissou |
| author_sort | Mutsa Makaza |
| collection | DOAJ |
| description | Introduction: Data on aplastic anemia (AA) is currently very scarce in Africa and Zimbabwe, despite rising cases of acquire aplastic anemia (AAA) observed among young men. We explore AAA risk factors, hematological parameters, patient prevalence, and control. Materials and Methods: This is a case-control study. We reviewed cases of AAA admitted in a referral hospital receiving hematological consultation in Parirenyatwa Group of Hospital Zimbabwe 2020–2022. Male patients 15 years and above were grouped into two groups: AAA cases and controls selected from the same institute admitted for other hematological conditions. Hematological characteristics, sociodemographic, and exposure risk factors were compiled. Odds ratios and 95% CI were computed. Records including’ full blood count, peripheral smear, occupation, and underlying conditions were presented as mean, percentage, chi-square test, and t-test were set at P < 0.05 as statistically significant. Results: Most AAA were in the age range of 24–30. Urban residency is significantly associated with AAA; 100% of AAA have no history of familial AA. No statistical significance in hematological parameters was observed between AAA cases and control by chi-square and t-test. The global prevalence of AAA was 27%, 5.59% had hepatitis, 4.34% were HIV positive, 2.27% had prostate cancer, and 36 AAA cases had pancytopenia. The chi-square test indicated risk factors medication, chloramphenicol, HIV, and hepatitis are not associated with AAA at the opposite of pancytopenia 36 points of AAA (82%). Conclusion: No significant difference in the hematological parameter in AAA cases versus control. The prevalence of AAA was 27%, which is high compared to other African countries. The majority of AAA cases have pancytopenia (82%). Residency, age, hepatitis, and HIV risk factors were related to AAA. |
| first_indexed | 2024-03-11T14:45:02Z |
| format | Article |
| id | doaj.art-1c146392afe24ead9d6ff13dad2b6677 |
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| issn | 2347-7946 2347-7962 |
| language | English |
| last_indexed | 2024-03-11T14:45:02Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | MGM Journal of Medical Sciences |
| spelling | doaj.art-1c146392afe24ead9d6ff13dad2b66772023-10-30T11:43:57ZengWolters Kluwer Medknow PublicationsMGM Journal of Medical Sciences2347-79462347-79622023-01-0110221021710.4103/mgmj.mgmj_50_23Prevalence and risk factors of acquired aplastic anemia among men aged 15 years and above referred for hematological consultation at Parirenyatwa Group of Hospital Zimbabwe 2020–2022: A case-control studyMutsa MakazaAbdoul Razak Mahaman YacoubouMaibouge Tanko Mahamane SalissouIntroduction: Data on aplastic anemia (AA) is currently very scarce in Africa and Zimbabwe, despite rising cases of acquire aplastic anemia (AAA) observed among young men. We explore AAA risk factors, hematological parameters, patient prevalence, and control. Materials and Methods: This is a case-control study. We reviewed cases of AAA admitted in a referral hospital receiving hematological consultation in Parirenyatwa Group of Hospital Zimbabwe 2020–2022. Male patients 15 years and above were grouped into two groups: AAA cases and controls selected from the same institute admitted for other hematological conditions. Hematological characteristics, sociodemographic, and exposure risk factors were compiled. Odds ratios and 95% CI were computed. Records including’ full blood count, peripheral smear, occupation, and underlying conditions were presented as mean, percentage, chi-square test, and t-test were set at P < 0.05 as statistically significant. Results: Most AAA were in the age range of 24–30. Urban residency is significantly associated with AAA; 100% of AAA have no history of familial AA. No statistical significance in hematological parameters was observed between AAA cases and control by chi-square and t-test. The global prevalence of AAA was 27%, 5.59% had hepatitis, 4.34% were HIV positive, 2.27% had prostate cancer, and 36 AAA cases had pancytopenia. The chi-square test indicated risk factors medication, chloramphenicol, HIV, and hepatitis are not associated with AAA at the opposite of pancytopenia 36 points of AAA (82%). Conclusion: No significant difference in the hematological parameter in AAA cases versus control. The prevalence of AAA was 27%, which is high compared to other African countries. The majority of AAA cases have pancytopenia (82%). Residency, age, hepatitis, and HIV risk factors were related to AAA.http://www.mgmjms.com/article.asp?issn=2347-7946;year=2023;volume=10;issue=2;spage=210;epage=217;aulast=Makazaacquired aplastic anemiahematological alterationprevalencerisk factors |
| spellingShingle | Mutsa Makaza Abdoul Razak Mahaman Yacoubou Maibouge Tanko Mahamane Salissou Prevalence and risk factors of acquired aplastic anemia among men aged 15 years and above referred for hematological consultation at Parirenyatwa Group of Hospital Zimbabwe 2020–2022: A case-control study MGM Journal of Medical Sciences acquired aplastic anemia hematological alteration prevalence risk factors |
| title | Prevalence and risk factors of acquired aplastic anemia among men aged 15 years and above referred for hematological consultation at Parirenyatwa Group of Hospital Zimbabwe 2020–2022: A case-control study |
| title_full | Prevalence and risk factors of acquired aplastic anemia among men aged 15 years and above referred for hematological consultation at Parirenyatwa Group of Hospital Zimbabwe 2020–2022: A case-control study |
| title_fullStr | Prevalence and risk factors of acquired aplastic anemia among men aged 15 years and above referred for hematological consultation at Parirenyatwa Group of Hospital Zimbabwe 2020–2022: A case-control study |
| title_full_unstemmed | Prevalence and risk factors of acquired aplastic anemia among men aged 15 years and above referred for hematological consultation at Parirenyatwa Group of Hospital Zimbabwe 2020–2022: A case-control study |
| title_short | Prevalence and risk factors of acquired aplastic anemia among men aged 15 years and above referred for hematological consultation at Parirenyatwa Group of Hospital Zimbabwe 2020–2022: A case-control study |
| title_sort | prevalence and risk factors of acquired aplastic anemia among men aged 15 years and above referred for hematological consultation at parirenyatwa group of hospital zimbabwe 2020 2022 a case control study |
| topic | acquired aplastic anemia hematological alteration prevalence risk factors |
| url | http://www.mgmjms.com/article.asp?issn=2347-7946;year=2023;volume=10;issue=2;spage=210;epage=217;aulast=Makaza |
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