Indian Childhood Cirrhosis: Case Report and Pediatric Diagnostic Challenges
Introduction: Indian childhood cirrhosis is a chronic liver disease usually seen in paediatric age group and is unique to the Indian subcontinent. The definitive causative factor for the disease is not found till now but excess copper ingestion has been associated with it.Case presentation: An India...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2015-08-01
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| Series: | International Journal of Pediatrics |
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| Online Access: | http://ijp.mums.ac.ir/pdf_4796_bcaedb3ed2e005cad302a06583467c24.html |
| _version_ | 1798040850968608768 |
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| author | Jaivinder Yadav Deepak Sharma Suman Yadav Sweta Shastri |
| author_facet | Jaivinder Yadav Deepak Sharma Suman Yadav Sweta Shastri |
| author_sort | Jaivinder Yadav |
| collection | DOAJ |
| description | Introduction: Indian childhood cirrhosis is a chronic liver disease usually seen in paediatric age group and is unique to the Indian subcontinent. The definitive causative factor for the disease is not found till now but excess copper ingestion has been associated with it.Case presentation: An Indian origin one and half year old premorbidly normal male child presented with history of gradual distension of abdomen for 6 months and jaundice, generalized body swelling, high colour urine for 20 days. There was no history of any bleeding or feature suggestive of hepatic encephalopathy. On physical examination child was icteric, pale and had anasarca, massive hepatosplenomegaly and ascites. The child was evaluated for various causes of hepatic failure in pediatric age group including infective, metabolic and autoimmune etiologies. Unfortunately the child succumbed to the illness. The post-mortem liver biopsy and copper estimation cleared the air, revealing Indian childhood cirrhosis as the underlying etiology.Conclusion: Though Indian childhood cirrhosis is a rare entity and reported less frequently in literature, the treating pediatrician should keep this as a differential in case of pediatric hepatic failure. The liver biopsy and hepatic copper estimation are the gold standard diagnostic tests for diagnosing Indian Childhood cirrhosis. |
| first_indexed | 2024-04-11T22:13:22Z |
| format | Article |
| id | doaj.art-1c14dc7a065e4e308473e2eae57d8b34 |
| institution | Directory Open Access Journal |
| issn | 2345-5047 2345-5055 |
| language | English |
| last_indexed | 2024-04-11T22:13:22Z |
| publishDate | 2015-08-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj.art-1c14dc7a065e4e308473e2eae57d8b342022-12-22T04:00:29ZengMashhad University of Medical SciencesInternational Journal of Pediatrics2345-50472345-50552015-08-0135.18658694796Indian Childhood Cirrhosis: Case Report and Pediatric Diagnostic ChallengesJaivinder Yadav0Deepak Sharma1Suman Yadav2Sweta Shastri3PGIMS Rohtak, India.Department of Neonatology, Fernandez Hospital, Hyderabad, India.Department of Anatomy, University College of Medical Sciences, Delhi, India.ACPM Medical College, Dhule, Maharashtra, India.Introduction: Indian childhood cirrhosis is a chronic liver disease usually seen in paediatric age group and is unique to the Indian subcontinent. The definitive causative factor for the disease is not found till now but excess copper ingestion has been associated with it.Case presentation: An Indian origin one and half year old premorbidly normal male child presented with history of gradual distension of abdomen for 6 months and jaundice, generalized body swelling, high colour urine for 20 days. There was no history of any bleeding or feature suggestive of hepatic encephalopathy. On physical examination child was icteric, pale and had anasarca, massive hepatosplenomegaly and ascites. The child was evaluated for various causes of hepatic failure in pediatric age group including infective, metabolic and autoimmune etiologies. Unfortunately the child succumbed to the illness. The post-mortem liver biopsy and copper estimation cleared the air, revealing Indian childhood cirrhosis as the underlying etiology.Conclusion: Though Indian childhood cirrhosis is a rare entity and reported less frequently in literature, the treating pediatrician should keep this as a differential in case of pediatric hepatic failure. The liver biopsy and hepatic copper estimation are the gold standard diagnostic tests for diagnosing Indian Childhood cirrhosis.http://ijp.mums.ac.ir/pdf_4796_bcaedb3ed2e005cad302a06583467c24.htmlChildhood cirrhosisCopperMallory hyaline bodies |
| spellingShingle | Jaivinder Yadav Deepak Sharma Suman Yadav Sweta Shastri Indian Childhood Cirrhosis: Case Report and Pediatric Diagnostic Challenges International Journal of Pediatrics Childhood cirrhosis Copper Mallory hyaline bodies |
| title | Indian Childhood Cirrhosis: Case Report and Pediatric Diagnostic Challenges |
| title_full | Indian Childhood Cirrhosis: Case Report and Pediatric Diagnostic Challenges |
| title_fullStr | Indian Childhood Cirrhosis: Case Report and Pediatric Diagnostic Challenges |
| title_full_unstemmed | Indian Childhood Cirrhosis: Case Report and Pediatric Diagnostic Challenges |
| title_short | Indian Childhood Cirrhosis: Case Report and Pediatric Diagnostic Challenges |
| title_sort | indian childhood cirrhosis case report and pediatric diagnostic challenges |
| topic | Childhood cirrhosis Copper Mallory hyaline bodies |
| url | http://ijp.mums.ac.ir/pdf_4796_bcaedb3ed2e005cad302a06583467c24.html |
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