Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress
There have been many reports on the relationship between mitochondrial oxidative stress and various types of diseases. This review covers mitochondrial targeting photodynamic therapy and photothermal therapy as a therapeutic strategy for inducing mitochondrial oxidative stress. We also discuss other...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/1/83 |
| _version_ | 1819024018315935744 |
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| author | Yuma Yamada Yuta Takano Satrialdi Jiro Abe Mitsue Hibino Hideyoshi Harashima |
| author_facet | Yuma Yamada Yuta Takano Satrialdi Jiro Abe Mitsue Hibino Hideyoshi Harashima |
| author_sort | Yuma Yamada |
| collection | DOAJ |
| description | There have been many reports on the relationship between mitochondrial oxidative stress and various types of diseases. This review covers mitochondrial targeting photodynamic therapy and photothermal therapy as a therapeutic strategy for inducing mitochondrial oxidative stress. We also discuss other mitochondrial targeting phototherapeutic methods. In addition, we discuss anti-oxidant therapy by a mitochondrial drug delivery system (DDS) as a therapeutic strategy for suppressing oxidative stress. We also describe cell therapy for reducing oxidative stress in mitochondria. Finally, we discuss the possibilities and problems associated with clinical applications of mitochondrial DDS to regulate mitochondrial oxidative stress. |
| first_indexed | 2024-12-21T04:48:07Z |
| format | Article |
| id | doaj.art-1c17da1be7064335b07fe1e3e84983f9 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-12-21T04:48:07Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-1c17da1be7064335b07fe1e3e84983f92022-12-21T19:15:31ZengMDPI AGBiomolecules2218-273X2020-01-011018310.3390/biom10010083biom10010083Therapeutic Strategies for Regulating Mitochondrial Oxidative StressYuma Yamada0Yuta Takano1Satrialdi2Jiro Abe3Mitsue Hibino4Hideyoshi Harashima5Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, JapanResearch Institute for Electronic Science, Hokkaido University, Kita-20 Nishi-10, Kita-ku, Sapporo 001-0020, JapanFaculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, JapanDepartment of Pediatrics, Graduate School of Medicine, Hokkaido University, Kita-15, Nishi 7, Kita-ku, Sapporo 060-8638, JapanFaculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, JapanFaculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, JapanThere have been many reports on the relationship between mitochondrial oxidative stress and various types of diseases. This review covers mitochondrial targeting photodynamic therapy and photothermal therapy as a therapeutic strategy for inducing mitochondrial oxidative stress. We also discuss other mitochondrial targeting phototherapeutic methods. In addition, we discuss anti-oxidant therapy by a mitochondrial drug delivery system (DDS) as a therapeutic strategy for suppressing oxidative stress. We also describe cell therapy for reducing oxidative stress in mitochondria. Finally, we discuss the possibilities and problems associated with clinical applications of mitochondrial DDS to regulate mitochondrial oxidative stress.https://www.mdpi.com/2218-273X/10/1/83mitochondriaoxidative stressphotodynamic therapycancer therapyantioxidant therapycell therapydrug delivery systemliposomesmito-porter |
| spellingShingle | Yuma Yamada Yuta Takano Satrialdi Jiro Abe Mitsue Hibino Hideyoshi Harashima Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress Biomolecules mitochondria oxidative stress photodynamic therapy cancer therapy antioxidant therapy cell therapy drug delivery system liposomes mito-porter |
| title | Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress |
| title_full | Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress |
| title_fullStr | Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress |
| title_full_unstemmed | Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress |
| title_short | Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress |
| title_sort | therapeutic strategies for regulating mitochondrial oxidative stress |
| topic | mitochondria oxidative stress photodynamic therapy cancer therapy antioxidant therapy cell therapy drug delivery system liposomes mito-porter |
| url | https://www.mdpi.com/2218-273X/10/1/83 |
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