Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs

Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroid...

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Main Authors: Tae Young Park, Hyoung-Chul Oh, Evan L. Fogel, Glen A. Lehman
Format: Article
Language:English
Published: The Korean Association of Internal Medicine 2020-05-01
Series:The Korean Journal of Internal Medicine
Subjects:
Online Access:http://www.kjim.org/upload/pdf/kjim-2020-069.pdf
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author Tae Young Park
Hyoung-Chul Oh
Evan L. Fogel
Glen A. Lehman
author_facet Tae Young Park
Hyoung-Chul Oh
Evan L. Fogel
Glen A. Lehman
author_sort Tae Young Park
collection DOAJ
description Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroidal anti-inflammatory drugs (NSAIDs) have opened a new era for its prevention. This review focuses on the role of NSAIDs in pancreatitis, the pharmacokinetics of these agents, and summarizes the results of clinical trials with rectal NSAIDs alone and combination regimens in the prevention of post-ERCP pancreatitis.
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spelling doaj.art-1c19051d8e474a108b40e5b384aa89b42022-12-21T22:28:11ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482020-05-0135353554310.3904/kjim.2020.069170368Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugsTae Young Park0Hyoung-Chul Oh1Evan L. Fogel2Glen A. Lehman3 Department of Internal Medicine, Inje University Seoul Paik Hospital, Seoul, Korea Division of Gastroenterology, Chung-Ang University College of Medicine, Seoul, Korea Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USAAcute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroidal anti-inflammatory drugs (NSAIDs) have opened a new era for its prevention. This review focuses on the role of NSAIDs in pancreatitis, the pharmacokinetics of these agents, and summarizes the results of clinical trials with rectal NSAIDs alone and combination regimens in the prevention of post-ERCP pancreatitis.http://www.kjim.org/upload/pdf/kjim-2020-069.pdfcholangiopancreatography, endoscopic retrogradepancreatitisanti-inflammatory agents, non-steroidal
spellingShingle Tae Young Park
Hyoung-Chul Oh
Evan L. Fogel
Glen A. Lehman
Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
The Korean Journal of Internal Medicine
cholangiopancreatography, endoscopic retrograde
pancreatitis
anti-inflammatory agents, non-steroidal
title Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
title_full Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
title_fullStr Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
title_full_unstemmed Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
title_short Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs
title_sort prevention of post endoscopic retrograde cholangiopancreatography pancreatitis with rectal non steroidal anti inflammatory drugs
topic cholangiopancreatography, endoscopic retrograde
pancreatitis
anti-inflammatory agents, non-steroidal
url http://www.kjim.org/upload/pdf/kjim-2020-069.pdf
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AT evanlfogel preventionofpostendoscopicretrogradecholangiopancreatographypancreatitiswithrectalnonsteroidalantiinflammatorydrugs
AT glenalehman preventionofpostendoscopicretrogradecholangiopancreatographypancreatitiswithrectalnonsteroidalantiinflammatorydrugs