Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity
Cornus officinalis, a kind of edible herbal medicine, has been widely used in the protection of liver and kidney due to its medicinal and nutritional effect. Its anti-inflammatory, anti-tumor, and anti-oxidant activities can be enhanced by wine-steamed (WS) processing. Based on the activations of he...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.807071/full |
| _version_ | 1818027618089304064 |
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| author | Xin Han Chuan Ding Yan Ning QiYuan Shan Minjie Niu Hao Cai Peng Xu Gang Cao |
| author_facet | Xin Han Chuan Ding Yan Ning QiYuan Shan Minjie Niu Hao Cai Peng Xu Gang Cao |
| author_sort | Xin Han |
| collection | DOAJ |
| description | Cornus officinalis, a kind of edible herbal medicine, has been widely used in the protection of liver and kidney due to its medicinal and nutritional effect. Its anti-inflammatory, anti-tumor, and anti-oxidant activities can be enhanced by wine-steamed (WS) processing. Based on the activations of hepatic stellate cells-T6 (HSC-T6) and HK-2, our study used single-factor plus orthogonal design to investigate the anti-fibrosis of C. officinalis processed with steamed (S), high-pressure steamed (HPS), WS, high-pressure wine-steamed (HPWS), wine-dipped (WD), and wine-fried (WF). The chemical constituents in processed C. officinalis with higher anti-fibrotic activities were detected by ultra-high performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Results showed that C. officinalis with HPWS significantly inhibited the activations of HSC-T6 and HK-2. Moreover, compounds in C. officinalis with HPWS were obtained via UHPLC-Q-TOF-MS/MS, indicating that 27 components were changed compared with raw C. officinalis. These results demonstrated that HPWS is the optimal processing technology for anti-fibrosis of C. officinalis. |
| first_indexed | 2024-12-10T04:50:45Z |
| format | Article |
| id | doaj.art-1c1a69b2b1504effb574983005b9783e |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-10T04:50:45Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-1c1a69b2b1504effb574983005b9783e2022-12-22T02:01:37ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-05-01910.3389/fnut.2022.807071807071Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic ActivityXin Han0Chuan Ding1Yan Ning2QiYuan Shan3Minjie Niu4Hao Cai5Peng Xu6Gang Cao7School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, ChinaThe Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, ChinaCornus officinalis, a kind of edible herbal medicine, has been widely used in the protection of liver and kidney due to its medicinal and nutritional effect. Its anti-inflammatory, anti-tumor, and anti-oxidant activities can be enhanced by wine-steamed (WS) processing. Based on the activations of hepatic stellate cells-T6 (HSC-T6) and HK-2, our study used single-factor plus orthogonal design to investigate the anti-fibrosis of C. officinalis processed with steamed (S), high-pressure steamed (HPS), WS, high-pressure wine-steamed (HPWS), wine-dipped (WD), and wine-fried (WF). The chemical constituents in processed C. officinalis with higher anti-fibrotic activities were detected by ultra-high performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Results showed that C. officinalis with HPWS significantly inhibited the activations of HSC-T6 and HK-2. Moreover, compounds in C. officinalis with HPWS were obtained via UHPLC-Q-TOF-MS/MS, indicating that 27 components were changed compared with raw C. officinalis. These results demonstrated that HPWS is the optimal processing technology for anti-fibrosis of C. officinalis.https://www.frontiersin.org/articles/10.3389/fnut.2022.807071/fullCornus officinalisfibrosiswine steamedprocessing technologycomposition difference |
| spellingShingle | Xin Han Chuan Ding Yan Ning QiYuan Shan Minjie Niu Hao Cai Peng Xu Gang Cao Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity Frontiers in Nutrition Cornus officinalis fibrosis wine steamed processing technology composition difference |
| title | Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity |
| title_full | Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity |
| title_fullStr | Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity |
| title_full_unstemmed | Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity |
| title_short | Optimizing Processing Technology of Cornus officinalis: Based on Anti-Fibrotic Activity |
| title_sort | optimizing processing technology of cornus officinalis based on anti fibrotic activity |
| topic | Cornus officinalis fibrosis wine steamed processing technology composition difference |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.807071/full |
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