Pan-Genomic Sequencing Reveals Actionable <i>CDKN2A/2B</i> Deletions and Kataegis in Anaplastic Thyroid Carcinoma

Pan-Genomic Sequencing Reveals Actionable <i>CDKN2A/2B</i> Deletions and Kataegis in Anaplastic Thyroid Carcinoma

Anaplastic thyroid carcinoma (ATC) is a lethal malignancy characterized by poor response to conventional therapies. Whole-genome sequencing (WGS) analyses of this tumor type are limited, and we therefore interrogated eight ATCs using WGS and RNA sequencing. Five out of eight cases (63%) displayed &l...

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Bibliographic Details
Main Authors: Adam Stenman, Minjun Yang, Johan O. Paulsson, Jan Zedenius, Kajsa Paulsson, C. Christofer Juhlin
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
anaplastic thyroid carcinoma
whole-genome sequencing
CDKN2A
CDKN2B
kataegis
molecular targets
Online Access:https://www.mdpi.com/2072-6694/13/24/6340

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