Management of a complicated case of liver transplant patient with multiple alloantibodies
The focus of transfusion services is now shifting toward the prevention of alloimmunization and delayed hemolysis, especially in multi-transfused patients. Here, we present a complex case of a multitransfused chronic liver disease patient, alloimmunized with multiple Rh antibodies posted for a liver...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Global Journal of Transfusion Medicine |
| Subjects: | |
| Online Access: | http://www.gjtmonline.com/article.asp?issn=2468-8398;year=2019;volume=4;issue=1;spage=90;epage=92;aulast=Agarwal |
| _version_ | 1819118154440245248 |
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| author | Nitin Agarwal Prashant Pandey Mukesh Kumar Anurag Kumar |
| author_facet | Nitin Agarwal Prashant Pandey Mukesh Kumar Anurag Kumar |
| author_sort | Nitin Agarwal |
| collection | DOAJ |
| description | The focus of transfusion services is now shifting toward the prevention of alloimmunization and delayed hemolysis, especially in multi-transfused patients. Here, we present a complex case of a multitransfused chronic liver disease patient, alloimmunized with multiple Rh antibodies posted for a liver transplant. Our blood bank successfully managed this patient and was able to supply the required blood components on time to save his life. A 28-year-old male patient was admitted to our hospital for the liver transplant. Blood bank could not find compatible blood units for the patient. The patient antibody screen was positive and the pattern was suggestive of anti-E antibody, but few other antibodies such as C, K, Fyb, and N could not be ruled out. Eluate showed the same result on antibody screening. The patient serum was alloadsorbed with “rr” blood using conventional tube technique. Adsorbed patient serum showed the pattern of hidden anti-C and we confirmed that patient serum contained anti-E and anti-C antibodies. As “e” antigen is a high prevalence antigen, we could not find an e negative unit and only C negative unit could be provided to the patient without any untoward incidence. |
| first_indexed | 2024-12-22T05:44:22Z |
| format | Article |
| id | doaj.art-1c1b52d2b18a48279778c762f86aeb5a |
| institution | Directory Open Access Journal |
| issn | 2468-8398 2455-8893 |
| language | English |
| last_indexed | 2024-12-22T05:44:22Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Global Journal of Transfusion Medicine |
| spelling | doaj.art-1c1b52d2b18a48279778c762f86aeb5a2022-12-21T18:37:06ZengWolters Kluwer Medknow PublicationsGlobal Journal of Transfusion Medicine2468-83982455-88932019-01-0141909210.4103/GJTM.GJTM_49_18Management of a complicated case of liver transplant patient with multiple alloantibodiesNitin AgarwalPrashant PandeyMukesh KumarAnurag KumarThe focus of transfusion services is now shifting toward the prevention of alloimmunization and delayed hemolysis, especially in multi-transfused patients. Here, we present a complex case of a multitransfused chronic liver disease patient, alloimmunized with multiple Rh antibodies posted for a liver transplant. Our blood bank successfully managed this patient and was able to supply the required blood components on time to save his life. A 28-year-old male patient was admitted to our hospital for the liver transplant. Blood bank could not find compatible blood units for the patient. The patient antibody screen was positive and the pattern was suggestive of anti-E antibody, but few other antibodies such as C, K, Fyb, and N could not be ruled out. Eluate showed the same result on antibody screening. The patient serum was alloadsorbed with “rr” blood using conventional tube technique. Adsorbed patient serum showed the pattern of hidden anti-C and we confirmed that patient serum contained anti-E and anti-C antibodies. As “e” antigen is a high prevalence antigen, we could not find an e negative unit and only C negative unit could be provided to the patient without any untoward incidence.http://www.gjtmonline.com/article.asp?issn=2468-8398;year=2019;volume=4;issue=1;spage=90;epage=92;aulast=AgarwalAdsorptionalloimmunizationantibody identificationanti-Canti-eelutionmultiple alloantibodies |
| spellingShingle | Nitin Agarwal Prashant Pandey Mukesh Kumar Anurag Kumar Management of a complicated case of liver transplant patient with multiple alloantibodies Global Journal of Transfusion Medicine Adsorption alloimmunization antibody identification anti-C anti-e elution multiple alloantibodies |
| title | Management of a complicated case of liver transplant patient with multiple alloantibodies |
| title_full | Management of a complicated case of liver transplant patient with multiple alloantibodies |
| title_fullStr | Management of a complicated case of liver transplant patient with multiple alloantibodies |
| title_full_unstemmed | Management of a complicated case of liver transplant patient with multiple alloantibodies |
| title_short | Management of a complicated case of liver transplant patient with multiple alloantibodies |
| title_sort | management of a complicated case of liver transplant patient with multiple alloantibodies |
| topic | Adsorption alloimmunization antibody identification anti-C anti-e elution multiple alloantibodies |
| url | http://www.gjtmonline.com/article.asp?issn=2468-8398;year=2019;volume=4;issue=1;spage=90;epage=92;aulast=Agarwal |
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