Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy
Hemodialysis is a life-sustaining therapy for millions of people worldwide. However, despite considerable technical and scientific improvements, results are still not fully satisfactory in terms of morbidity and mortality. The membrane contained in the hemodialyzer is undoubtedly the main determinan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/4/844 |
| _version_ | 1797436731359756288 |
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| author | Mario Bonomini Luca Piscitani Lorenzo Di Liberato Vittorio Sirolli |
| author_facet | Mario Bonomini Luca Piscitani Lorenzo Di Liberato Vittorio Sirolli |
| author_sort | Mario Bonomini |
| collection | DOAJ |
| description | Hemodialysis is a life-sustaining therapy for millions of people worldwide. However, despite considerable technical and scientific improvements, results are still not fully satisfactory in terms of morbidity and mortality. The membrane contained in the hemodialyzer is undoubtedly the main determinant of the success and quality of hemodialysis therapy. Membrane properties influence solute removal and the interactions with blood components that define the membrane’s biocompatibility. Bioincompatibility is considered a potential contributor to several uremic complications. Thus, the development of more biocompatible polymers used as hemodialyzer membrane is of utmost importance for improving results and clinical patient outcomes. Many different surface-modified membranes for hemodialysis have been manufactured over recent years by varying approaches in the attempt to minimize blood incompatibility. Their main characteristics and clinical results in hemodialysis patients were reviewed in the present article. |
| first_indexed | 2024-03-09T11:06:47Z |
| format | Article |
| id | doaj.art-1c1d7be5e0d341b1b66089e22c0a87b6 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T11:06:47Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1c1d7be5e0d341b1b66089e22c0a87b62023-12-01T00:54:12ZengMDPI AGBiomedicines2227-90592022-04-0110484410.3390/biomedicines10040844Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis TherapyMario Bonomini0Luca Piscitani1Lorenzo Di Liberato2Vittorio Sirolli3Nephrology and Dialysis Unit, Department of Medicine, G. d’Annunzio University, Chieti-Pescara, SS. Annunziata Hospital, Via dei Vestini, 66013 Chieti, ItalyNephrology and Dialysis Unit, Department of Medicine, San Salvatore Hospital, Via Vetoio, 67100 L’Aquila, ItalyNephrology and Dialysis Unit, Department of Medicine, G. d’Annunzio University, Chieti-Pescara, SS. Annunziata Hospital, Via dei Vestini, 66013 Chieti, ItalyNephrology and Dialysis Unit, Department of Medicine, G. d’Annunzio University, Chieti-Pescara, SS. Annunziata Hospital, Via dei Vestini, 66013 Chieti, ItalyHemodialysis is a life-sustaining therapy for millions of people worldwide. However, despite considerable technical and scientific improvements, results are still not fully satisfactory in terms of morbidity and mortality. The membrane contained in the hemodialyzer is undoubtedly the main determinant of the success and quality of hemodialysis therapy. Membrane properties influence solute removal and the interactions with blood components that define the membrane’s biocompatibility. Bioincompatibility is considered a potential contributor to several uremic complications. Thus, the development of more biocompatible polymers used as hemodialyzer membrane is of utmost importance for improving results and clinical patient outcomes. Many different surface-modified membranes for hemodialysis have been manufactured over recent years by varying approaches in the attempt to minimize blood incompatibility. Their main characteristics and clinical results in hemodialysis patients were reviewed in the present article.https://www.mdpi.com/2227-9059/10/4/844biocompatibilityhemodialysismembranebiomaterialprotein adsorptioncoagulation |
| spellingShingle | Mario Bonomini Luca Piscitani Lorenzo Di Liberato Vittorio Sirolli Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy Biomedicines biocompatibility hemodialysis membrane biomaterial protein adsorption coagulation |
| title | Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy |
| title_full | Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy |
| title_fullStr | Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy |
| title_full_unstemmed | Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy |
| title_short | Biocompatibility of Surface-Modified Membranes for Chronic Hemodialysis Therapy |
| title_sort | biocompatibility of surface modified membranes for chronic hemodialysis therapy |
| topic | biocompatibility hemodialysis membrane biomaterial protein adsorption coagulation |
| url | https://www.mdpi.com/2227-9059/10/4/844 |
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