<sup>68</sup>Ga-DOTATOC PET/CT Follow Up after Single or Hypofractionated Gamma Knife ICON Radiosurgery for Meningioma Patients
<sup>68</sup>Ga-DOTATOC represents a useful tool in tumor contouring for radiosurgery planning. We present a case series of patients affected by meningiomas on who we performed <sup>68</sup>Ga-DOTATOC positron emission tomography (PET)/CT pre-operatively, a subgroup of which...
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MDPI AG
2021-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/3/375 |
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| author | Fabio Barone Francesco Inserra Gianluca Scalia Massimo Ippolito Sebastiano Cosentino Antonio Crea Maria Gabriella Sabini Lucia Valastro Iolanda Valeria Patti Stefania Mele Grazia Acquaviva Alessandra Tocco Maria Tamburo Francesca Graziano Ottavio S. Tomasi Rosario Maugeri Gerardo Iacopino Salvatore Cicero Lidia Strigari Giuseppe Emmanuele Umana |
| author_facet | Fabio Barone Francesco Inserra Gianluca Scalia Massimo Ippolito Sebastiano Cosentino Antonio Crea Maria Gabriella Sabini Lucia Valastro Iolanda Valeria Patti Stefania Mele Grazia Acquaviva Alessandra Tocco Maria Tamburo Francesca Graziano Ottavio S. Tomasi Rosario Maugeri Gerardo Iacopino Salvatore Cicero Lidia Strigari Giuseppe Emmanuele Umana |
| author_sort | Fabio Barone |
| collection | DOAJ |
| description | <sup>68</sup>Ga-DOTATOC represents a useful tool in tumor contouring for radiosurgery planning. We present a case series of patients affected by meningiomas on who we performed <sup>68</sup>Ga-DOTATOC positron emission tomography (PET)/CT pre-operatively, a subgroup of which also underwent a post-operative <sup>68</sup>Ga-DOTATOC PET/CT to evaluate the standardized uptake value (SUV) modification after Gamma Knife ICON treatment in single or hypofractionated fractions. Twenty patients were enrolled/included in this study: ten females and ten males. The median age was 52 years (range 33–80). The median tumor diameter was 3.68 cm (range 0.12–22.26 cm), and the median pre-radiotherapy maximum SUV value was 11 (range 2.3–92). The average of the relative percentage changes between SUVs at baseline and follow up was −6%, ranging from −41% to 56%. The SUV was reduced in seven out of 12 patients (58%), stable in two out of 12 (17%), and increased in three out of 12 (25%), suggesting a biological response of the tumor to the Gamma Knife treatment in most of the cases. <sup>68</sup>Ga-DOTATOC-PET represents a valuable tool in assessing the meningioma diagnosis for primary radiosurgery; it is also promising for follow-up assessment. |
| first_indexed | 2024-03-10T13:12:16Z |
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| id | doaj.art-1c1de99ab4684877bf7856151cfc5a46 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T13:12:16Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
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| series | Brain Sciences |
| spelling | doaj.art-1c1de99ab4684877bf7856151cfc5a462023-11-21T10:36:50ZengMDPI AGBrain Sciences2076-34252021-03-0111337510.3390/brainsci11030375<sup>68</sup>Ga-DOTATOC PET/CT Follow Up after Single or Hypofractionated Gamma Knife ICON Radiosurgery for Meningioma PatientsFabio Barone0Francesco Inserra1Gianluca Scalia2Massimo Ippolito3Sebastiano Cosentino4Antonio Crea5Maria Gabriella Sabini6Lucia Valastro7Iolanda Valeria Patti8Stefania Mele9Grazia Acquaviva10Alessandra Tocco11Maria Tamburo12Francesca Graziano13Ottavio S. Tomasi14Rosario Maugeri15Gerardo Iacopino16Salvatore Cicero17Lidia Strigari18Giuseppe Emmanuele Umana19Gamma-Knife Center, Department of Neurosurgery, Cannizzaro Hospital, 95126 Catania, ItalyGamma-Knife Center, Department of Neurosurgery, Cannizzaro Hospital, 95126 Catania, ItalyNeurosurgery Unit, Highly Specialized Hospital and of National Importance “Garibaldi”, 95122 Catania, ItalyDepartment of Advanced Technologies, Nuclear Medicine and PET Cannizzaro Hospital, 95126 Catania, ItalyDepartment of Advanced Technologies, Nuclear Medicine and PET Cannizzaro Hospital, 95126 Catania, ItalyTrauma Center, Gamma Knife Center, Department of Neurosurgery, Cannizzaro Hospital, 95126 Catania, ItalyMedical Physics Unit, Cannizzaro Hospital, 95126 Catania, ItalyMedical Physics Unit, Cannizzaro Hospital, 95126 Catania, ItalyMedical Physics Unit, Cannizzaro Hospital, 95126 Catania, ItalyMedical Physics Unit, Cannizzaro Hospital, 95126 Catania, ItalyUOC Radioterapia AOOE Cannizzaro di Catania, 95100 Catania, ItalyUOC Radioterapia AOOE Cannizzaro di Catania, 95100 Catania, ItalyCannizzaro Hospital, 95100 Catania, ItalyNeurosurgery Unit, Highly Specialized Hospital and of National Importance “Garibaldi”, 95122 Catania, ItalyDepartment of Neurological Surgery Christian Doppler Klinik, Paracelsus Medical University Salzburg, 5020 Salzburg, AustriaNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyNeurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, ItalyTrauma Center, Gamma Knife Center, Department of Neurosurgery, Cannizzaro Hospital, 95126 Catania, ItalyDepartment of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyTrauma Center, Gamma Knife Center, Department of Neurosurgery, Cannizzaro Hospital, 95126 Catania, Italy<sup>68</sup>Ga-DOTATOC represents a useful tool in tumor contouring for radiosurgery planning. We present a case series of patients affected by meningiomas on who we performed <sup>68</sup>Ga-DOTATOC positron emission tomography (PET)/CT pre-operatively, a subgroup of which also underwent a post-operative <sup>68</sup>Ga-DOTATOC PET/CT to evaluate the standardized uptake value (SUV) modification after Gamma Knife ICON treatment in single or hypofractionated fractions. Twenty patients were enrolled/included in this study: ten females and ten males. The median age was 52 years (range 33–80). The median tumor diameter was 3.68 cm (range 0.12–22.26 cm), and the median pre-radiotherapy maximum SUV value was 11 (range 2.3–92). The average of the relative percentage changes between SUVs at baseline and follow up was −6%, ranging from −41% to 56%. The SUV was reduced in seven out of 12 patients (58%), stable in two out of 12 (17%), and increased in three out of 12 (25%), suggesting a biological response of the tumor to the Gamma Knife treatment in most of the cases. <sup>68</sup>Ga-DOTATOC-PET represents a valuable tool in assessing the meningioma diagnosis for primary radiosurgery; it is also promising for follow-up assessment.https://www.mdpi.com/2076-3425/11/3/375<sup>68</sup>Ga-DOTATOC PET/CTmeningiomaGamma Kniferadiosurgeryfollow uphypofractionated |
| spellingShingle | Fabio Barone Francesco Inserra Gianluca Scalia Massimo Ippolito Sebastiano Cosentino Antonio Crea Maria Gabriella Sabini Lucia Valastro Iolanda Valeria Patti Stefania Mele Grazia Acquaviva Alessandra Tocco Maria Tamburo Francesca Graziano Ottavio S. Tomasi Rosario Maugeri Gerardo Iacopino Salvatore Cicero Lidia Strigari Giuseppe Emmanuele Umana <sup>68</sup>Ga-DOTATOC PET/CT Follow Up after Single or Hypofractionated Gamma Knife ICON Radiosurgery for Meningioma Patients Brain Sciences <sup>68</sup>Ga-DOTATOC PET/CT meningioma Gamma Knife radiosurgery follow up hypofractionated |
| title | <sup>68</sup>Ga-DOTATOC PET/CT Follow Up after Single or Hypofractionated Gamma Knife ICON Radiosurgery for Meningioma Patients |
| title_full | <sup>68</sup>Ga-DOTATOC PET/CT Follow Up after Single or Hypofractionated Gamma Knife ICON Radiosurgery for Meningioma Patients |
| title_fullStr | <sup>68</sup>Ga-DOTATOC PET/CT Follow Up after Single or Hypofractionated Gamma Knife ICON Radiosurgery for Meningioma Patients |
| title_full_unstemmed | <sup>68</sup>Ga-DOTATOC PET/CT Follow Up after Single or Hypofractionated Gamma Knife ICON Radiosurgery for Meningioma Patients |
| title_short | <sup>68</sup>Ga-DOTATOC PET/CT Follow Up after Single or Hypofractionated Gamma Knife ICON Radiosurgery for Meningioma Patients |
| title_sort | sup 68 sup ga dotatoc pet ct follow up after single or hypofractionated gamma knife icon radiosurgery for meningioma patients |
| topic | <sup>68</sup>Ga-DOTATOC PET/CT meningioma Gamma Knife radiosurgery follow up hypofractionated |
| url | https://www.mdpi.com/2076-3425/11/3/375 |
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