Three Decades of Atherosclerotic Reno-vascular Disease Management - Changing Outcomes in an Observational Study
Background/Aims: Optimized medical therapy has improved cardiovascular outcomes in the general population. To investigate whether changes in the management of atherosclerotic renovascular disease (ARVD) have had an impact on clinical outcomes. Methods: Recruitment into this single-center prospective...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2016-05-01
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| Series: | Kidney & Blood Pressure Research |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/443434 |
| _version_ | 1828761461233549312 |
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| author | Diana Vassallo Darren Green James Ritchie Constantina Chrysochou James Blunt Philip A. Kalra |
| author_facet | Diana Vassallo Darren Green James Ritchie Constantina Chrysochou James Blunt Philip A. Kalra |
| author_sort | Diana Vassallo |
| collection | DOAJ |
| description | Background/Aims: Optimized medical therapy has improved cardiovascular outcomes in the general population. To investigate whether changes in the management of atherosclerotic renovascular disease (ARVD) have had an impact on clinical outcomes. Methods: Recruitment into this single-center prospective cohort study started in 1986. Data was analyzed retrospectively. Patients were divided into four groups based on relationship of diagnosis year to landmark randomized controlled trials (RCT); group 1 - pre-large RCT data (1986-2000); group 2 - post-early RCT (2001-2004); group 3 - ASTRAL study recruitment era (2004-2009); group 4 - post-ASTRAL (2009-2014). Results: In total, 872 patients were followed for a median 54.9 months (IQR 20.2-96.2). Over successive time-periods, there was an increase in baseline utilization of renin angiotensin blockade (RAB) (group 4: 69% vs. group 1: 31%, pConclusions: Although fewer patients are being investigated for ARVD in our center, these have more cardiovascular comorbidities. Nonetheless, optimized medical therapy may have contributed towards improved proteinuria, renal function and clinical outcomes in patients diagnosed with ARVD. |
| first_indexed | 2024-12-11T01:30:33Z |
| format | Article |
| id | doaj.art-1c1f4c92c59a4aafaa21444374b15bb6 |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-11T01:30:33Z |
| publishDate | 2016-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-1c1f4c92c59a4aafaa21444374b15bb62022-12-22T01:25:23ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432016-05-0141332533410.1159/000443434443434Three Decades of Atherosclerotic Reno-vascular Disease Management - Changing Outcomes in an Observational StudyDiana VassalloDarren GreenJames RitchieConstantina ChrysochouJames BluntPhilip A. KalraBackground/Aims: Optimized medical therapy has improved cardiovascular outcomes in the general population. To investigate whether changes in the management of atherosclerotic renovascular disease (ARVD) have had an impact on clinical outcomes. Methods: Recruitment into this single-center prospective cohort study started in 1986. Data was analyzed retrospectively. Patients were divided into four groups based on relationship of diagnosis year to landmark randomized controlled trials (RCT); group 1 - pre-large RCT data (1986-2000); group 2 - post-early RCT (2001-2004); group 3 - ASTRAL study recruitment era (2004-2009); group 4 - post-ASTRAL (2009-2014). Results: In total, 872 patients were followed for a median 54.9 months (IQR 20.2-96.2). Over successive time-periods, there was an increase in baseline utilization of renin angiotensin blockade (RAB) (group 4: 69% vs. group 1: 31%, pConclusions: Although fewer patients are being investigated for ARVD in our center, these have more cardiovascular comorbidities. Nonetheless, optimized medical therapy may have contributed towards improved proteinuria, renal function and clinical outcomes in patients diagnosed with ARVD.http://www.karger.com/Article/FullText/443434Atherosclerotic renovascular diseaseChronic Kidney DiseaseEpidemiologyRenal revascularizationVascular protective therapy |
| spellingShingle | Diana Vassallo Darren Green James Ritchie Constantina Chrysochou James Blunt Philip A. Kalra Three Decades of Atherosclerotic Reno-vascular Disease Management - Changing Outcomes in an Observational Study Kidney & Blood Pressure Research Atherosclerotic renovascular disease Chronic Kidney Disease Epidemiology Renal revascularization Vascular protective therapy |
| title | Three Decades of Atherosclerotic Reno-vascular Disease Management - Changing Outcomes in an Observational Study |
| title_full | Three Decades of Atherosclerotic Reno-vascular Disease Management - Changing Outcomes in an Observational Study |
| title_fullStr | Three Decades of Atherosclerotic Reno-vascular Disease Management - Changing Outcomes in an Observational Study |
| title_full_unstemmed | Three Decades of Atherosclerotic Reno-vascular Disease Management - Changing Outcomes in an Observational Study |
| title_short | Three Decades of Atherosclerotic Reno-vascular Disease Management - Changing Outcomes in an Observational Study |
| title_sort | three decades of atherosclerotic reno vascular disease management changing outcomes in an observational study |
| topic | Atherosclerotic renovascular disease Chronic Kidney Disease Epidemiology Renal revascularization Vascular protective therapy |
| url | http://www.karger.com/Article/FullText/443434 |
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