Short-term evaluation of motor and sensory nerve conduction parameters in COVID-19-associated peripheral neuropathy patients
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) is mostly associated with upper and lower respiratory tract manifestations. However, coronavirus disease 19 (COVID-19) can result in a wide range of other systemic symptomatology, including neuropsychiatric, psychologic...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-03-01
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| Series: | The Egyptian Journal of Bronchology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43168-023-00189-3 |
| _version_ | 1797827623460536320 |
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| author | Ahmad M. Shaddad Aliaë A. R. Mohammed Hussein Amal Mohamed Aly Tohamy Waleed Gamal Elddine Khalil |
| author_facet | Ahmad M. Shaddad Aliaë A. R. Mohammed Hussein Amal Mohamed Aly Tohamy Waleed Gamal Elddine Khalil |
| author_sort | Ahmad M. Shaddad |
| collection | DOAJ |
| description | Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) is mostly associated with upper and lower respiratory tract manifestations. However, coronavirus disease 19 (COVID-19) can result in a wide range of other systemic symptomatology, including neuropsychiatric, psychological, and psychosocial impairments. Literature regarding neurological compromise, including neuropathy and sensory and motor affection associated with COVID-19, is still limited. This study aims to evaluate the sensory, motor neuropathy, and secondary neurological impairment among patients with mild to moderate coronavirus disease associated with peripheral neuropathy within 1 month. Methods Forty participants, including 20 mild to moderate COVID-19 patients with peripheral neuropathy and 20 age and gender-matched healthy volunteers, were recruited in this case/control study. Laboratory evaluation focused on C-reactive protein (CRP) and D-dimer levels. Oxygen saturation for all participants was recorded. The neurophysiological study included motor nerve study, sensory nerve study, and F wave study for upper and lower limbs were done. Results The two groups were similar regarding baseline data. Neurological symptoms’ onset in the COVID-19 group ranged from 4 to 24 days. Levels of CRP and D-dimer levels were significantly higher in patients versus the control group. Motor nerve conduction (MNC) amplitude and latency for the median nerve were significantly compromised among the COVID-19 group. The MNC latency and F wave latency for the posterior tibial nerve were significantly higher in the COVID-19 group. The CRP and D-dimer levels were associated with a significant positive correlation with a latency of median nerve MNC, sensory nerve conduction (SNC), and f-wave; latency of MNC and F wave of the posterior tibial nerve; and SNC latency for sural nerve. Conclusion neurological involvement can occur in mild to moderate cases of SARS-COV-2 infection and add to the burden of the disease. Neurological symptoms in the course of COVID-19 disease should be interpreted cautiously, and appropriate diagnosis, including nerve conduction studies and management, should be considered. Trial registration ClinicalTrials.gov. NCT05721040. |
| first_indexed | 2024-04-09T12:51:18Z |
| format | Article |
| id | doaj.art-1c1fe4154f07443aaaedfa359b007a41 |
| institution | Directory Open Access Journal |
| issn | 2314-8551 |
| language | English |
| last_indexed | 2024-04-09T12:51:18Z |
| publishDate | 2023-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Bronchology |
| spelling | doaj.art-1c1fe4154f07443aaaedfa359b007a412023-05-14T11:10:47ZengSpringerOpenThe Egyptian Journal of Bronchology2314-85512023-03-011711810.1186/s43168-023-00189-3Short-term evaluation of motor and sensory nerve conduction parameters in COVID-19-associated peripheral neuropathy patientsAhmad M. Shaddad0Aliaë A. R. Mohammed Hussein1Amal Mohamed Aly Tohamy2Waleed Gamal Elddine Khalil3Chest Department, Faculty of Medicine, Assiut UniversityChest Department, Faculty of Medicine, Assiut UniversityNeuropsychiatry Department, Faculty of Medicine, Assiut UniversityChest Department, Faculty of Medicine, Assiut UniversityAbstract Background Severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) is mostly associated with upper and lower respiratory tract manifestations. However, coronavirus disease 19 (COVID-19) can result in a wide range of other systemic symptomatology, including neuropsychiatric, psychological, and psychosocial impairments. Literature regarding neurological compromise, including neuropathy and sensory and motor affection associated with COVID-19, is still limited. This study aims to evaluate the sensory, motor neuropathy, and secondary neurological impairment among patients with mild to moderate coronavirus disease associated with peripheral neuropathy within 1 month. Methods Forty participants, including 20 mild to moderate COVID-19 patients with peripheral neuropathy and 20 age and gender-matched healthy volunteers, were recruited in this case/control study. Laboratory evaluation focused on C-reactive protein (CRP) and D-dimer levels. Oxygen saturation for all participants was recorded. The neurophysiological study included motor nerve study, sensory nerve study, and F wave study for upper and lower limbs were done. Results The two groups were similar regarding baseline data. Neurological symptoms’ onset in the COVID-19 group ranged from 4 to 24 days. Levels of CRP and D-dimer levels were significantly higher in patients versus the control group. Motor nerve conduction (MNC) amplitude and latency for the median nerve were significantly compromised among the COVID-19 group. The MNC latency and F wave latency for the posterior tibial nerve were significantly higher in the COVID-19 group. The CRP and D-dimer levels were associated with a significant positive correlation with a latency of median nerve MNC, sensory nerve conduction (SNC), and f-wave; latency of MNC and F wave of the posterior tibial nerve; and SNC latency for sural nerve. Conclusion neurological involvement can occur in mild to moderate cases of SARS-COV-2 infection and add to the burden of the disease. Neurological symptoms in the course of COVID-19 disease should be interpreted cautiously, and appropriate diagnosis, including nerve conduction studies and management, should be considered. Trial registration ClinicalTrials.gov. NCT05721040.https://doi.org/10.1186/s43168-023-00189-3COVID-19Nerve conduction studiesPeripheral neuropathyComplicationMotor and sensory functionNerve conduction velocity |
| spellingShingle | Ahmad M. Shaddad Aliaë A. R. Mohammed Hussein Amal Mohamed Aly Tohamy Waleed Gamal Elddine Khalil Short-term evaluation of motor and sensory nerve conduction parameters in COVID-19-associated peripheral neuropathy patients The Egyptian Journal of Bronchology COVID-19 Nerve conduction studies Peripheral neuropathy Complication Motor and sensory function Nerve conduction velocity |
| title | Short-term evaluation of motor and sensory nerve conduction parameters in COVID-19-associated peripheral neuropathy patients |
| title_full | Short-term evaluation of motor and sensory nerve conduction parameters in COVID-19-associated peripheral neuropathy patients |
| title_fullStr | Short-term evaluation of motor and sensory nerve conduction parameters in COVID-19-associated peripheral neuropathy patients |
| title_full_unstemmed | Short-term evaluation of motor and sensory nerve conduction parameters in COVID-19-associated peripheral neuropathy patients |
| title_short | Short-term evaluation of motor and sensory nerve conduction parameters in COVID-19-associated peripheral neuropathy patients |
| title_sort | short term evaluation of motor and sensory nerve conduction parameters in covid 19 associated peripheral neuropathy patients |
| topic | COVID-19 Nerve conduction studies Peripheral neuropathy Complication Motor and sensory function Nerve conduction velocity |
| url | https://doi.org/10.1186/s43168-023-00189-3 |
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