Vinpocetine alleviated alveolar epithelial cells injury in experimental pulmonary fibrosis by targeting PPAR-γ/NLRP3/NF-κB and TGF-β1/Smad2/3 pathways

Vinpocetine alleviated alveolar epithelial cells injury in experimental pulmonary fibrosis by targeting PPAR-γ/NLRP3/NF-κB and TGF-β1/Smad2/3 pathways

Abstract This study aimed to investigate the potential anti-fibrotic activity of vinpocetine in an experimental model of pulmonary fibrosis by bleomycin and in the MRC-5 cell line. Pulmonary fibrosis was induced in BALB/c mice by oropharyngeal aspiration of a single dose of bleomycin (5 mg/kg). The...

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Bibliographic Details
Main Authors: Zeena A. Hussein, Ahmed R. Abu-Raghif, Nibras J. Tahseen, Khalid A. Rashed, Nada S. Shaker, Hayder Adnan Fawzi
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Scientific Reports
Subjects:
Bleomycin-induced pulmonary fibrosis
MRC-5 cell line
NLRP3 inflammasome
PPAR-γ
TGF-β1/Smad2/3 pathway
Vinpocetine
Online Access:https://doi.org/10.1038/s41598-024-61269-y

Internet

https://doi.org/10.1038/s41598-024-61269-y

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