Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration

Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration

Objective: Zinc transporter 8 (ZnT8) is a major humoral target in human type 1 diabetes (T1D). Polymorphic variants of Slc30A8, which encodes ZnT8, are also associated with protection from type 2 diabetes (T2D). The current study examined whether ZnT8 might play a role beyond simply being a target o...

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Bibliographic Details
Main Authors: Yong Kyung Kim, Jay A. Walters, Nicole D. Moss, Kristen L. Wells, Ryan Sheridan, Jose G. Miranda, Richard K.P. Benninger, Laura L. Pyle, Richard M. O'Brien, Lori Sussel, Howard W. Davidson
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Metabolism
Subjects:
Type 1 diabetes
Zinc transporter 8
Mitochondria
NOD mouse
Islets of langerhans
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822002010

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