High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum
Purpose High-contrast tissue characterization of thermal ablation has been desired to evaluate therapeutic outcomes accurately. This paper presents a photoacoustic (PA) characterization of thermal tissue ablation in the visible spectrum, in which higher light absorbance can produce spectral contrast...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Ultrasound in Medicine
2023-04-01
|
| Series: | Ultrasonography |
| Subjects: | |
| Online Access: | http://www.e-ultrasonography.org/upload/usg-22171.pdf |
| _version_ | 1827974199700881408 |
|---|---|
| author | Hyunjae Song Tai-Kyong Song Jeeun Kang |
| author_facet | Hyunjae Song Tai-Kyong Song Jeeun Kang |
| author_sort | Hyunjae Song |
| collection | DOAJ |
| description | Purpose High-contrast tissue characterization of thermal ablation has been desired to evaluate therapeutic outcomes accurately. This paper presents a photoacoustic (PA) characterization of thermal tissue ablation in the visible spectrum, in which higher light absorbance can produce spectral contrast starker than in the near-infrared range. Methods Ex vivo experiments were performed to measure visible PA spectra (480–700 nm) from fresh porcine liver tissues that received a thermal dose in a range of cumulative equivalent minutes at 43°C (CEM43). The local hemoglobin lobe area between 510–600 nm and whole-spectral area under the curve were evaluated to represent the transition of hemoglobin into methemoglobin (MetHb) in the target tissue. Results The thermal process below an estimated therapeutic CEM43 threshold (80–340 minutes) presented a progressive elevation of the PA spectrum and an eventual loss of local hemoglobin peaks in the visible spectrum, closer to the MetHb spectrum. Interestingly, an excessive CEM43 produced a substantial drop in the PA spectrum. In the spectral analysis, the visible spectrum yielded 13.9–34.1 times higher PA sensitivity and 1.42 times higher contrast change than at a near-infrared wavelength. Conclusion This novel method of PA tissue characterization in the visible spectrum could be a potential modality to evaluate various thermal therapeutic modalities at high-contrast resolution. |
| first_indexed | 2024-04-09T19:50:33Z |
| format | Article |
| id | doaj.art-1c22ae5301714d67b5107974d5b58b30 |
| institution | Directory Open Access Journal |
| issn | 2288-5943 |
| language | English |
| last_indexed | 2024-04-09T19:50:33Z |
| publishDate | 2023-04-01 |
| publisher | Korean Society of Ultrasound in Medicine |
| record_format | Article |
| series | Ultrasonography |
| spelling | doaj.art-1c22ae5301714d67b5107974d5b58b302023-04-03T06:45:11ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59432023-04-0142224925810.14366/usg.221711650High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrumHyunjae Song0Tai-Kyong Song1Jeeun Kang2 Department of Electronic Engineering, Sogang University, Korea Department of Electronic Engineering, Sogang University, Korea Laboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, MD, USAPurpose High-contrast tissue characterization of thermal ablation has been desired to evaluate therapeutic outcomes accurately. This paper presents a photoacoustic (PA) characterization of thermal tissue ablation in the visible spectrum, in which higher light absorbance can produce spectral contrast starker than in the near-infrared range. Methods Ex vivo experiments were performed to measure visible PA spectra (480–700 nm) from fresh porcine liver tissues that received a thermal dose in a range of cumulative equivalent minutes at 43°C (CEM43). The local hemoglobin lobe area between 510–600 nm and whole-spectral area under the curve were evaluated to represent the transition of hemoglobin into methemoglobin (MetHb) in the target tissue. Results The thermal process below an estimated therapeutic CEM43 threshold (80–340 minutes) presented a progressive elevation of the PA spectrum and an eventual loss of local hemoglobin peaks in the visible spectrum, closer to the MetHb spectrum. Interestingly, an excessive CEM43 produced a substantial drop in the PA spectrum. In the spectral analysis, the visible spectrum yielded 13.9–34.1 times higher PA sensitivity and 1.42 times higher contrast change than at a near-infrared wavelength. Conclusion This novel method of PA tissue characterization in the visible spectrum could be a potential modality to evaluate various thermal therapeutic modalities at high-contrast resolution.http://www.e-ultrasonography.org/upload/usg-22171.pdfspectroscopicphotoacousticthermal ablationtissue characterizationvisible spectrum |
| spellingShingle | Hyunjae Song Tai-Kyong Song Jeeun Kang High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum Ultrasonography spectroscopic photoacoustic thermal ablation tissue characterization visible spectrum |
| title | High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum |
| title_full | High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum |
| title_fullStr | High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum |
| title_full_unstemmed | High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum |
| title_short | High-contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum |
| title_sort | high contrast spectroscopic photoacoustic characterization of thermal tissue ablation in the visible spectrum |
| topic | spectroscopic photoacoustic thermal ablation tissue characterization visible spectrum |
| url | http://www.e-ultrasonography.org/upload/usg-22171.pdf |
| work_keys_str_mv | AT hyunjaesong highcontrastspectroscopicphotoacousticcharacterizationofthermaltissueablationinthevisiblespectrum AT taikyongsong highcontrastspectroscopicphotoacousticcharacterizationofthermaltissueablationinthevisiblespectrum AT jeeunkang highcontrastspectroscopicphotoacousticcharacterizationofthermaltissueablationinthevisiblespectrum |