A New Fluorescent Probe for Hydrogen Sulfide Detection in Solution and Living Cells
Since Hydrogen Sulfide (H<sub>2</sub>S) was recognized as a gas transmitter, its detection and quantification have become a hot research topic among chemists and biologists. In this area, fluorescent probes have shown great advantages: fast and strong response, low detection limit and ea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/17/6195 |
| Summary: | Since Hydrogen Sulfide (H<sub>2</sub>S) was recognized as a gas transmitter, its detection and quantification have become a hot research topic among chemists and biologists. In this area, fluorescent probes have shown great advantages: fast and strong response, low detection limit and easy manipulation. Here we developed a new fluorescent probe that detected H<sub>2</sub>S selectively among various bioactive and inorganic salts. This probe was based on the core structure of fluorescein and reacted with H<sub>2</sub>S through azide-reduction. Great linearity was achieved correlating fluorescence intensity and H<sub>2</sub>S concentrations in solution. The detection of H<sub>2</sub>S in cancer cells was also achieved. |
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| ISSN: | 1420-3049 |