Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients
Fibroblast growth factors (FGFs) are involved in numerous metabolic processes. The endocrine subfamily of FGFs, consisting of FGF19, FGF21, and FGF23, might have beneficial effects in the treatment of diabetes mellitus (DM) and/or obesity. The analog with the greatest potential, FGF21, lowers blood...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.1086987/full |
| _version_ | 1797957579758895104 |
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| author | Ronald J. Corbee Dion L. van Everdingen Hans S. Kooistra Louis C. Penning |
| author_facet | Ronald J. Corbee Dion L. van Everdingen Hans S. Kooistra Louis C. Penning |
| author_sort | Ronald J. Corbee |
| collection | DOAJ |
| description | Fibroblast growth factors (FGFs) are involved in numerous metabolic processes. The endocrine subfamily of FGFs, consisting of FGF19, FGF21, and FGF23, might have beneficial effects in the treatment of diabetes mellitus (DM) and/or obesity. The analog with the greatest potential, FGF21, lowers blood glucose levels, improves insulin sensitivity, and induces weight loss in several animal models. In this review we summarize recent (pre)clinical findings with FGF21 analogs in animal models and men. Furthermore, possible applications of FGF21 analogs for pets with DM will be discussed. As currently, information about the use of FGF21 analogs in pet animals is scarce. |
| first_indexed | 2024-04-11T00:07:22Z |
| format | Article |
| id | doaj.art-1c25f7377e25473ba3851ac1c9f8584d |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-11T00:07:22Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-1c25f7377e25473ba3851ac1c9f8584d2023-01-09T10:20:27ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-01-01910.3389/fvets.2022.10869871086987Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patientsRonald J. CorbeeDion L. van EverdingenHans S. KooistraLouis C. PenningFibroblast growth factors (FGFs) are involved in numerous metabolic processes. The endocrine subfamily of FGFs, consisting of FGF19, FGF21, and FGF23, might have beneficial effects in the treatment of diabetes mellitus (DM) and/or obesity. The analog with the greatest potential, FGF21, lowers blood glucose levels, improves insulin sensitivity, and induces weight loss in several animal models. In this review we summarize recent (pre)clinical findings with FGF21 analogs in animal models and men. Furthermore, possible applications of FGF21 analogs for pets with DM will be discussed. As currently, information about the use of FGF21 analogs in pet animals is scarce.https://www.frontiersin.org/articles/10.3389/fvets.2022.1086987/fullglucosemetabolismobesityinsulinFGFendocrine |
| spellingShingle | Ronald J. Corbee Dion L. van Everdingen Hans S. Kooistra Louis C. Penning Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients Frontiers in Veterinary Science glucose metabolism obesity insulin FGF endocrine |
| title | Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients |
| title_full | Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients |
| title_fullStr | Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients |
| title_full_unstemmed | Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients |
| title_short | Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients |
| title_sort | fibroblast growth factor 21 fgf21 analogs as possible treatment options for diabetes mellitus in veterinary patients |
| topic | glucose metabolism obesity insulin FGF endocrine |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.1086987/full |
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