Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against <i>Candida</i> spp. Biofilm Infections
The aim of this study was to improve the treatment of <i>Candida albicans</i> biofilms through the use of nystatin solid dispersions developed using maltodextrins as a hyperosmotic carrier. Characterization studies by differential scanning calorimetry, X-ray diffraction, dissolution stud...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/14/5/397 |
| _version_ | 1797536696548458496 |
|---|---|
| author | Carlos Benavent Carlos Torrado-Salmerón Santiago Torrado-Santiago |
| author_facet | Carlos Benavent Carlos Torrado-Salmerón Santiago Torrado-Santiago |
| author_sort | Carlos Benavent |
| collection | DOAJ |
| description | The aim of this study was to improve the treatment of <i>Candida albicans</i> biofilms through the use of nystatin solid dispersions developed using maltodextrins as a hyperosmotic carrier. Characterization studies by differential scanning calorimetry, X-ray diffraction, dissolution studies, and particle size analysis were performed to evaluate changes in nystatin crystallinity. Antifungal activity and anti-biofilm efficacy were assessed by microbiological techniques. The results for nystatin solid dispersions showed that the enhancement of antifungal activity may be related to the high proportions of maltodextrins. Anti-biofilm assays showed a significant reduction (more than 80%) on biofilm formation with SD-N:MD [1:6] compared to the nystatin reference suspension. The elaboration process and physicochemical properties of SD-N:MD [1:6] could be a promising strategy for treatment of Candida biofilms. |
| first_indexed | 2024-03-10T12:04:27Z |
| format | Article |
| id | doaj.art-1c2905a3efd34a89a95ab2b5c83d5e8d |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T12:04:27Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-1c2905a3efd34a89a95ab2b5c83d5e8d2023-11-21T16:39:13ZengMDPI AGPharmaceuticals1424-82472021-04-0114539710.3390/ph14050397Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against <i>Candida</i> spp. Biofilm InfectionsCarlos Benavent0Carlos Torrado-Salmerón1Santiago Torrado-Santiago2Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainDepartment of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainDepartment of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainThe aim of this study was to improve the treatment of <i>Candida albicans</i> biofilms through the use of nystatin solid dispersions developed using maltodextrins as a hyperosmotic carrier. Characterization studies by differential scanning calorimetry, X-ray diffraction, dissolution studies, and particle size analysis were performed to evaluate changes in nystatin crystallinity. Antifungal activity and anti-biofilm efficacy were assessed by microbiological techniques. The results for nystatin solid dispersions showed that the enhancement of antifungal activity may be related to the high proportions of maltodextrins. Anti-biofilm assays showed a significant reduction (more than 80%) on biofilm formation with SD-N:MD [1:6] compared to the nystatin reference suspension. The elaboration process and physicochemical properties of SD-N:MD [1:6] could be a promising strategy for treatment of Candida biofilms.https://www.mdpi.com/1424-8247/14/5/397solid dispersionnystatinamorphous formmaltodextrinbiofilms<i>Candida albicans</i> |
| spellingShingle | Carlos Benavent Carlos Torrado-Salmerón Santiago Torrado-Santiago Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against <i>Candida</i> spp. Biofilm Infections Pharmaceuticals solid dispersion nystatin amorphous form maltodextrin biofilms <i>Candida albicans</i> |
| title | Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against <i>Candida</i> spp. Biofilm Infections |
| title_full | Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against <i>Candida</i> spp. Biofilm Infections |
| title_fullStr | Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against <i>Candida</i> spp. Biofilm Infections |
| title_full_unstemmed | Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against <i>Candida</i> spp. Biofilm Infections |
| title_short | Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against <i>Candida</i> spp. Biofilm Infections |
| title_sort | development of a solid dispersion of nystatin with maltodextrin as a carrier agent improvements in antifungal efficacy against i candida i spp biofilm infections |
| topic | solid dispersion nystatin amorphous form maltodextrin biofilms <i>Candida albicans</i> |
| url | https://www.mdpi.com/1424-8247/14/5/397 |
| work_keys_str_mv | AT carlosbenavent developmentofasoliddispersionofnystatinwithmaltodextrinasacarrieragentimprovementsinantifungalefficacyagainsticandidaisppbiofilminfections AT carlostorradosalmeron developmentofasoliddispersionofnystatinwithmaltodextrinasacarrieragentimprovementsinantifungalefficacyagainsticandidaisppbiofilminfections AT santiagotorradosantiago developmentofasoliddispersionofnystatinwithmaltodextrinasacarrieragentimprovementsinantifungalefficacyagainsticandidaisppbiofilminfections |