CSF Free Light Chains as a Marker of Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis: A Blood-CSF Barrier Related Evaluation in a Large Cohort

CSF Free Light Chains as a Marker of Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis: A Blood-CSF Barrier Related Evaluation in a Large Cohort

Objectives: The importance of immunoglobulin G (IgG) oligoclonal bands (OCB) in the diagnosis of multiple sclerosis (MS) was reaffirmed again in the recently revised MS diagnostic criteria. Since OCB testing is based on non-quantitative techniques and demands considerable methodological experience,...

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Bibliographic Details
Main Authors: Makbule Senel, Fatemeh Mojib-Yezdani, Ulrike Braisch, Franziska Bachhuber, Jan Lewerenz, Albert C. Ludolph, Markus Otto, Hayrettin Tumani
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
immunoglobulin free light chains
oligoclonal bands
OCB
intrathecal IgG synthesis
IgG index
multiple sclerosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00641/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00641/full

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