Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors
Human blood cells all develop from haematopoietic stem cells (HSCs), classically thought to be multipotent. Here the authors show, using single-cell RNA-seq and functional assays, that loss of erythroid potential and commitment to the myelo-lymphoid lineage occurs within the purest HSC compartment t...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06442-4 |
| _version_ | 1818422033643470848 |
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| author | Serena Belluschi Emily F. Calderbank Valerio Ciaurro Blanca Pijuan-Sala Antonella Santoro Nicole Mende Evangelia Diamanti Kendig Yen Chi Sham Xiaonan Wang Winnie W. Y. Lau Wajid Jawaid Berthold Göttgens Elisa Laurenti |
| author_facet | Serena Belluschi Emily F. Calderbank Valerio Ciaurro Blanca Pijuan-Sala Antonella Santoro Nicole Mende Evangelia Diamanti Kendig Yen Chi Sham Xiaonan Wang Winnie W. Y. Lau Wajid Jawaid Berthold Göttgens Elisa Laurenti |
| author_sort | Serena Belluschi |
| collection | DOAJ |
| description | Human blood cells all develop from haematopoietic stem cells (HSCs), classically thought to be multipotent. Here the authors show, using single-cell RNA-seq and functional assays, that loss of erythroid potential and commitment to the myelo-lymphoid lineage occurs within the purest HSC compartment to date. |
| first_indexed | 2024-12-14T13:19:49Z |
| format | Article |
| id | doaj.art-1c2c1b37321a4167bfce7f9531b6a495 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:19:49Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1c2c1b37321a4167bfce7f9531b6a4952022-12-21T22:59:58ZengNature PortfolioNature Communications2041-17232018-10-019111510.1038/s41467-018-06442-4Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitorsSerena Belluschi0Emily F. Calderbank1Valerio Ciaurro2Blanca Pijuan-Sala3Antonella Santoro4Nicole Mende5Evangelia Diamanti6Kendig Yen Chi Sham7Xiaonan Wang8Winnie W. Y. Lau9Wajid Jawaid10Berthold Göttgens11Elisa Laurenti12Department of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeDepartment of Haematology and Wellcome and MRC Cambridge Stem Cell Institute, University of CambridgeHuman blood cells all develop from haematopoietic stem cells (HSCs), classically thought to be multipotent. Here the authors show, using single-cell RNA-seq and functional assays, that loss of erythroid potential and commitment to the myelo-lymphoid lineage occurs within the purest HSC compartment to date.https://doi.org/10.1038/s41467-018-06442-4 |
| spellingShingle | Serena Belluschi Emily F. Calderbank Valerio Ciaurro Blanca Pijuan-Sala Antonella Santoro Nicole Mende Evangelia Diamanti Kendig Yen Chi Sham Xiaonan Wang Winnie W. Y. Lau Wajid Jawaid Berthold Göttgens Elisa Laurenti Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors Nature Communications |
| title | Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors |
| title_full | Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors |
| title_fullStr | Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors |
| title_full_unstemmed | Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors |
| title_short | Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors |
| title_sort | myelo lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid primed multipotent progenitors |
| url | https://doi.org/10.1038/s41467-018-06442-4 |
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